摘要
Abstract
Objective:To investigate the influence of laparoscopic repair of duodenal ulcer perforation for traumatic stress and gastric mucosa VEGF,bFGF of patients.Method:A total of 90 patients with duodenal ulcer perforation who were admitted to Renhuai People's Hospital from January 2022 to January 2024 were selected as the research subjects.They were divided into the control group(open repair of duodenal ulcer perforation group,n=45)and the observation group(laparoscopic repair of duodenal ulcer perforation group,n=45)according to the random number table method.The operation indexes(operation time,intraoperative blood loss,postoperative body temperature and complication rates),recovery time of gastrointestinal function(bowel sound,exhaust and defecation time),traumatic stress[Interleukin(IL-1β),Leptin,Tumor necrosis factor-α(TNF-α)]and gastric mucosa VEGF,bFGF before and after the operation of two groups were compared.Result:There was no statistically significant difference in the operation time between the two group(P>0.05).The intraoperative blood loss of observation group was significantly less than that of control group,the postoperative body temperature of observation group was significantly lower than that of control group,the complication rate of obsenvation group was significantly lower than that of control group,the recovery time of gastrointestinal function were significantly shorter than those of control group,the traumatic stress of observation group at 3 and 5 day after the operation were significantly lower than those of control group,the gastric mucosa VEGF,bFGF expression levels of two groups at 4 week after the operation were significantly higher than those within group before the operation,the differences were all statistically significant(P<0.05).Conclusion:The difference of laparoscopic repair of duodenal ulcer perforation for lesion tissue repair is not significant to that of open operation,but its influence for degree of trauma response is relatively better.关键词
腹腔镜手术/开腹手术/十二指肠溃疡穿孔修补术/创伤应激/胃黏膜/血管内皮生长因子/碱性成纤维细胞生长因子Key words
Laparoscopic operation/Open operation/Repair of duodenal ulcer perforation/Traumatic stress/Gastric mucosa/Vascular endothelial growth factor/Basic fibroblast growth factor
