摘要
Abstract
Objective:To investigate the effects of joint cavity injection of Zhengqingfeng Tongning combined with glucosamine sulfate on knee joint function,serum interleukin-6(IL-6),tumor necvosis factor-α(TNF-α)levels,and bone metabolism markers in patients with knee osteoarthritis(KOA).Method:96 patients with knee osteoarthritis(KOA)admitted to the Second People's Hospital of Gansu Province from January 2024 to March 2025 were randomly divided into the Glucosamine Sulfate group and the Glucosamine Sulfate+Zhengqingfeng Tongning group by drawing lots,with 48 cases in each group.Both groups of patients received routine basic treatment.The GS group received treatment with glucosamine sulfate in addition to routine treatment,while the GS+ZT group received joint cavity injection of Zhengqingfeng Tongning in addition to routine treatment.The changes in knee joint function[Lysholm score,Western Ontario and McMaster University Osteoarthritis Index(WOMAC)],knee joint range of motion(ROM),serum inflammatory factors[IL-6,interleukin-17(IL-17),TNF-α],bone metabolism markers[cartilage oligomeric matrix protein(COMP),matrix metalloproteinase-13(MMP-13),osteocalcin(BGP)],and adverse reactions during medication between two groups were compared before and after treatment.Result:After treatment,the Lysholm score,ROM,and BGP of the GS+ZT group and GS group significantly increased compared to before treatment,and the above indicators of the GS+ZT group were higher than those of the GS group at the same time,with statistically significant differences(P<0.05).The WOMAC scores,as well as the levels of IL-6,IL-17,TNF-α,COMP,and MMP-13,decreased in both the GS+ZT group and the GS group compared to before treatment.The aforementioned indicators in the GS+ZT group were lower than those in the GS group at the same time,with statistically significant differences(P<0.05).During the treatment phase,no significant adverse reactions were reported in either group,and the difference was not statistically significant(P>0.05).Conclusion:The combination of Zhengqingfeng Tongning intra-articular injection and sulfated glucosamine can significantly improve knee joint function,reduce inflammation,and regulate bone metabolism in patients with knee osteoarthritis,with good safety and suitable for clinical application.关键词
正清风痛宁/关节腔注射/硫酸氨基葡萄糖/膝关节骨性关节炎/膝关节功能/血清炎症因子/骨代谢标志物Key words
Zhengqingfeng Tongning/Joint cavity injection/Glucosamine sulfate/Knee osteoarthritis/Knee joint function/Serum inflammatory factors/Bone metabolism markers
