中国中西医结合杂志2026，Vol.46Issue(5)：553-560,8.DOI:10.7661/j.cjim.20260126.033
黄厚止泻滴丸治疗腹泻型肠易激综合征临床研究
Clinical Research on Huanghou Zhixie Dripping Pills in Treating Diarrhea-Predominant Irritable Bowel Syndrome
摘要
Abstract
Objective To observe the effectiveness and mechanism of Huanghou Zhixie Dripping Pills(HZDP)in treating diarrhea-predominant irritable bowel syndrome(IBS-D).Methods A randomized controlled trial design was adopted to include 72 patients with IBS-D.Patients were randomly assigned to the treatment group(given HZDP for oral use)and the control group[given Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus Tablets,(live)for oral use],with 36 cases in each group.Additionally,20 healthy volunteers were enrolled as the healthy control group.Evaluation indicators included clinical efficacy,intestinal flora structure(assessed via 16S rRNA sequencing),bile acid profiles(analyzed by targeted metabolomics),serum inflammatory factors and markers of intestinal barrier function(measured by ELISA).Results After 4 weeks of treatment,the total effective rate of the treatment group(97.2％)was significantly higher than that of the control group(45.7％,x2=20.79,P＜0.01).Moreover,it also showed superior improvements in the Numerical Rating Scale(NRS)for abdominal pain,Bristol Stool Form Scale,and IBS Symptom Severity Scale(IBS-SSS)compared to the control group(P＜0.05).The analysis showed that HZDP could regulate the intestinal flora structure,manifested as increased in abundance of Bacteroidota and Prevotella_9,and decreased abundance of Firmicutes and pro-inflammatory genera(e.g.,Escherichia_Shigella),Additionally,it markedly reduced the concentration of 3-dehydrocholic acid(3-DHCA),a secondary bile acid,and significantly lowered the levels of serum pro-inflammatory factors(TNF-α,IL-6),5-hydroxytryptamine(5-HT),and markers of intestinal barrier damage(Zonulin and Calprotectin)(P＜0.01).Conclusions The total effective rate and symptom improvement effect of HZDP were both superior to those of Combined Bifidobacterium,Lactobacillus,Enterococcus and Bacillus cereus Tablets(live).Its therapeutic effect may be related to the coordinated regulation of the intestinal flora-bile acid metabolism-immune barrier network.关键词
黄厚止泻滴丸/腹泻型肠易激综合征/肠道菌群/胆汁酸代谢/免疫屏障/中药复方/随机对照研究Key words
Huanghou Zhixie Dripping Pills/diarrhea-predominant irritable bowel syndrome/intestinal flora/bile acid metabolism/immune barrier/Chinese herbal compound/randomized controlled trial引用本文复制引用
李晗旭,杨倩,王艺灿,霍永利,郎晓猛,康欣,杜朋丽,赵雯,白海燕..黄厚止泻滴丸治疗腹泻型肠易激综合征临床研究[J].中国中西医结合杂志,2026,46(5):553-560,8.基金项目
癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项(No.2024ZD0521004) （No.2024ZD0521004）
