中国中西医结合杂志2026，Vol.46Issue(5)：600-604,5.DOI:10.7661/j.cjim.20260320.039
溃疡性结肠炎湿热病机与湿热伏邪理论的现代研究
Modern Research on Dampness-Heat Pathogenesis and Dampness-Heat Latent Pathogen in Ulcerative Colitis
摘要
Abstract
The refractory character of ulcerative colitis(UC)is related to the basic pathophysiology of"lingering dampness-heat transforming into a latent pathogen",which captures the essence of the dampness-heat latent pathogen hypothesis.This academic discussion methodically delineates current research progress using this methodology.During the initial stage,dampness-heat alters the gut microbiota-metabolite axis,promoting pathogen latency and pro-inflammatory metabolite accumulation—the material foundation of the latent pathogen.In the progressive stage,dampness-heat congeals to initiate immune-inflammatory cascades,indicating a shift from quiescence to activation as an effector state.In the chronic persistent stage,the entrenched pathogen causes epigenetic changes that maintain inflammatory gene expression,resulting in a self-perpetuating"inflammation-epigenetics"cycle-the mechanism of pathological consolidation.Chinese medicine based on this idea offer multi-target therapeutic benefits at all stages.The purpose of this academic discussion is to provide a modern scientific foundation for the dampness-heat latent pathogen theory,as well as a theoretical underpinning for its clinical application.关键词
溃疡性结肠炎/湿热伏邪/菌群-代谢轴/免疫炎症/表观遗传/中医药Key words
ulcerative colitis/dampness-heat latent pathogen/microbiota-metabolism axis/immune inflammation/epigenetics/Chinese medicine引用本文复制引用
佘美龄,戴心怡,陈婷,张佳琪,唐旭东..溃疡性结肠炎湿热病机与湿热伏邪理论的现代研究[J].中国中西医结合杂志,2026,46(5):600-604,5.基金项目
国家自然科学基金专项项目(No.82341233) （No.82341233）
中国中医科学院西苑医院学术经验继承课题(No.0203064) （No.0203064）
中国中医科学院西苑医院中医药临床科研一体化平台建设专项(No.XYZX0405-34) （No.XYZX0405-34）
