中国现代中药2026，Vol.28Issue(5)：1039-1052,中插12-中插17,20.DOI:10.13313/j.issn.1673-4890.20251203004
龙血竭中黄酮类化合物及其代谢调控的进展
Advances in Studies of Flavonoids from Resina Draconis and Their Metabolic Regulation
摘要
Abstract
Resina Draconis,a traditional and precious Chinese medicine,is primarily derived from the resinous wood formed after injury to plants of the genus Dracaena.Flavonoids are its main active ingredients.This paper systematically reviewed the types and quantities of flavonoids identified in Resina Draconis,summarized the current research status of their biosynthetic pathways and regulatory mechanisms,and outlines future research directions.To date,a total of 170 flavonoids belonging to 11 major categories have been isolated and identified from Resina Draconis,with hydroxylation and O-methylation modifications being prominent features of its flavonoid constituents.Regarding metabolic regulation,existing studies have mainly focused on key enzyme genes involved in the early stages of biosynthesis,while research on key enzyme genes and their regulatory mechanisms in the downstream biosynthetic stages,particularly the post-modification stage,remains relatively limited.Future studies should focus on elucidating the transcriptional regulatory network of flavonoids in Resina Draconis and further exploring the functions and regulatory mechanisms of key post-modification enzymes,represented by O-methyltransferases,thereby providing theoretical guidance for developing efficient resin-induction techniques or enabling the biosynthesis of these compounds.关键词
龙血竭/龙血树/黄酮类化合物/生物合成途径/调控机制Key words
Resina Draconis/Dracaena tree/flavonoid compound/biosynthetic pathway/regulatory mechanism分类
医药卫生引用本文复制引用
马文静,张玉秀,吴海莹,蔡珊珊,刘久石,魏建和,刘培卫..龙血竭中黄酮类化合物及其代谢调控的进展[J].中国现代中药,2026,28(5):1039-1052,中插12-中插17,20.基金项目
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-031) （2021-I2M-1-031）
海南省科技专项(ZDYF2026SHFZ052) （ZDYF2026SHFZ052）
第二批海南省优秀人才团队建设(HNYT20240003) （HNYT20240003）
国家中医药管理局专项(GZY-KJS-2023-009) （GZY-KJS-2023-009）
