中国现代中药2026，Vol.28Issue(5)：1062-1073,12.DOI:10.13313/j.issn.1673-4890.20260116009
中药调控巨噬细胞极化防治射血分数保留型心力衰竭研究进展
Research Progress in Traditional Chinese Medicine Regulation of Macrophage Polarization for the Prevention and Treatment of Heart Failure with Preserved Ejection Fraction
摘要
Abstract
Heart failure with preserved ejection fraction(HFpEF)is a clinically prevalent form of heart failure,characterized by impaired ventricular diastolic function.Its high heterogeneity,progressive worsening,multiple comorbidities,and high mortality rate impose a heavy burden on patients.Its pathogenesis involves multiple mechanisms including myocardial inflammation,cardiac fibrosis,and mitochondrial dysfunction,with dysregulated macrophage polarization serving as a key driver.Macrophages exhibit two phenotypes:classically activated macrophages(M1 type)and alternatively activated macrophages(M2 type).In HFpEF,M1/M2 imbalance induces myocardial inflammation,promotes fibrosis and cardiac remodeling,and disrupts electrical conduction homeostasis,thereby exacerbating the pathological progression of HFpEF.Research indicates that traditional Chinese medicine(TCM)can modulate macrophage polarization balance through multi-component,multi-target mechanisms.This article summarizes the mechanisms of macrophage polarization in the pathogenesis of HFpEF.It systematically outlines how TCM exerts its core anti-inflammatory,anti-fibrotic,and cardiac function-improving effects by regulating macrophage polarization and balancing M1/M2 phenotypes via the transforming growth factor-β1/Smad(TGF-β1/Smads)signaling pathway and the phosphoinositide 3-kinase/protein kinase B(PI3K/Akt)signaling pathway.This provides novel insights and theoretical support for the application of TCM in the prevention and treatment of HFpEF.关键词
巨噬细胞极化/射血分数保留型心力衰竭/心力衰竭/中药Key words
macrophage polarization/heart failure with preserved ejection fraction/heart failure/traditional Chinese medicine分类
医药卫生引用本文复制引用
段礽妙,苏莹,翟芳芳,蒙占权..中药调控巨噬细胞极化防治射血分数保留型心力衰竭研究进展[J].中国现代中药,2026,28(5):1062-1073,12.基金项目
兰州市科技计划项目(2024-9-95) （2024-9-95）
甘肃省科技计划项目(21JR7RA583) （21JR7RA583）
