波谱学杂志2026，Vol.43Issue(2)：125-135,11.DOI:10.11938/cjmr20253179
基于纵向多自旋阶与Hadamard编码拥挤NMR谱解析
Resolving Crowded NMR Spectra Based on Longitudinal Multi-spin Order and Hadamard Encoding
摘要
Abstract
One-dimensional proton nuclear magnetic resonance(NMR)spectroscopy is a high-resolution,non-invasive technique widely used for structure elucidation and composition analysis.However,when applied to complex systems,its effectiveness is often hampered by overlapping peaks from similar chemical shifts and J-coupling,along with concentration variations obscuring weak signals from low-abundance compounds.To enhance the detection sensitivity for weak signals in crowded spectral regions,this work proposes Hadamard-DQF-LMO,integrating longitudinal multi-spin orders(LMOs),Hadamard encoding,and double quantum filtering(DQF).The approach utilizes DQF to selectively detect LMO signals while suppressing strong interference.The incorporation of polychromatic transition pulses and Hadamard-encoded 180° pulses enables parallel acquisition of multiple frequencies,which significantly improves both sensitivity and detection efficiency.Experiments on orange juice and mixed amino acid samples demonstrate peak separation with enhanced selectivity and signal-to-noise ratio(SNR),offering a novel and effective strategy for the NMR analysis of complex systems.关键词
磁共振波谱/Hadamard编码/纵向多自旋阶/二量子相干Key words
MRS/Hadamard encoding/longitudinal multi-spin orders/double quantum coherence分类
数理科学引用本文复制引用
李雪婷,梁伟,张欣彤,崔梦琪,林玉兰..基于纵向多自旋阶与Hadamard编码拥挤NMR谱解析[J].波谱学杂志,2026,43(2):125-135,11.基金项目
国家自然科学基金资助项目(12475297). （12475297）
