波谱学杂志2026，Vol.43Issue(2)：175-185,11.DOI:10.11938/cjmr20253177
二型糖尿病大鼠纹状体白质微观结构异常的磁共振影像研究
Magnetic Resonance Imaging Study on the Microstructure Abnormalities of Striatal White Matter in Type 2 Diabetic Mellitus Rats
摘要
Abstract
This study aims to explore the structural changes in white matter and the physiological mechanisms in type 2 diabetes mellitus(T2DM)rats by magnetic resonance imaging(MRI)technology.A T2DM model was established by 8 weeks of high-fat diet combined with intraperitoneal injection of a dose of 30 mg/kg streptozotocin(STZ).4 weeks after modeling,visual analysis of white matter in rats was performed by MRI,and the physiological mechanism of MRI index changes was further explained by immunohistology.The results showed that the striatal white matter volume decreased,the fractional anisotropy(FA),mean diffusivity(MD)and axial diffusivity(AD)decreased,and radial diffusivity(RD)increased in T2DM rats.Immunostain of phosphorylated neurofilament(SMI-31)and myelin basic protein(MBP)indicated axonal damage and demyelination of striatum in T2DM rats.In conclusion,the striatal injury in T2DM rats was observed by diffusion tensor imaging(DTI),and abnormal DTI index may be a manifestation of striatal axonal damage and demyelination,which can potentially be used as surrogates for evaluating diabetic brain injuries.关键词
磁共振成像/弥散张量成像/纹状体/二型糖尿病Key words
magnetic resonance imaging(MRI)/diffusion tensor imaging(DTI)/striatum/type 2 diabetes mellitus(T2DM)分类
数理科学引用本文复制引用
蔡悦,王旭霞,刘思婕,郭浩东,陈茜,程琳琳,康彦,林富春..二型糖尿病大鼠纹状体白质微观结构异常的磁共振影像研究[J].波谱学杂志,2026,43(2):175-185,11.基金项目
湖北省实验动物研究计划资助项目(T23H1401). （T23H1401）
