波谱学杂志2026，Vol.43Issue(2)：200-213,14.DOI:10.11938/cjmr20253181
蛋白冠原位调控增强肿瘤靶向19F MRI和联合治疗
In Situ Regulation of Protein Corona for Enhanced Tumor-targeted 19F MRI and Combined Therapy
摘要
Abstract
This study designed and constructed a pH-responsive intelligent theranostic nanoprobe.The nanoprobe utilizes perfluorocarbon nanoparticles with 19F magnetic resonance imaging(MRI)contrast capability as the core,with bovine serum albumin(BSA)adsorbed on the surface to form a"protein corona".Furthermore,tannic acid-iron(TA-FeⅢ)is complexed to create the core-shell structured PP@BSA-TAFeⅢ nanoparticles(NPs)probe.Owing to the unsaturated coordination state of Fe3+in TA-FeⅢ,the nanoprobe binds to transferrin upon entering the bloodstream,forming a"hybrid"protein corona and thereby achieving active targeting of transferrin receptors(TfR)hi ghly expressed on the tumor cell membrane.The nanoprobe efficiently accumulates in tumor tissue and generates a strong 19F-MRI signal,enabling highly sensitive tumor imaging.Upon entry into the acidic tumor microenvironment,Fe3+is released to induce ferroptosis,while TA-FeⅢ exhibits excellent photothermal effects,thereby achieving synergistic therapy.This in situ regulation strategy of protein corona offers a new approach for precise tumor diagnosis and therapy.关键词
19F磁共振成像/铁死亡/光热治疗Key words
19F magnetic resonance imaging(19F MRI)/ferroptosis/photothermal therapy分类
数理科学引用本文复制引用
李睿鹥,李莎,徐秋怡,隋美菊,陈世桢..蛋白冠原位调控增强肿瘤靶向19F MRI和联合治疗[J].波谱学杂志,2026,43(2):200-213,14.基金项目
国家自然科学基金资助项目(U21A20392,82127802,22404064,82102125) （U21A20392,82127802,22404064,82102125）
湖北省自然科学基金资助项目(2023BCB092) （2023BCB092）
中国科学院青年创新促进会资助项目(JCTD-2022-13). （JCTD-2022-13）
