川北医学院学报2026，Vol.41Issue(6)：669-672,4.DOI:10.3969/j.issn.1005-3697.2026.06.005
糖尿病视网膜病变患者NLR、PLR、LMR水平与黄斑中心凹无血管区损伤及预后的关系
Relationship between NLR,PLR,LMR and injury in foveal avascular zone,prognosis of patients with diabetic retinopathy
摘要
Abstract
Objective:To explore the relationship between neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),lymphocyte/monocyte ratio(LMR)and injury in foveal avascular zone(FAZ),prognosis of patients with diabetic retinopathy(DR).Methods:A total of 123 patients with DR were enrolled,and all underwent optical coherence tomography(OCTA).According to presence or absence of FAZ contour injury,patients were divided into injury group(n=60)and non-injury group(n=63),NLR,PLR and LMR levels in the two groups were compared.The relationship between FAZ contour injury and NLR,PLR,LMR were analyzed by Spearman.Taking whether there was visual disability after 1 year of follow-up as prognosis evaluation criteria,patients were divided into visual improvement group(n=86)and visual disability group(n=37),NLR,PLR and LMR levels in the two groups were compared.The predictive value of NLR,PLR and LMR levels for prognosis of DR was analyzed by ROC curves.Results:NLR and PLR in injury group were higher than those in non-injury group(P<0.05),while LMR was lower than that in non-injury group(P<0.05).NLR and PLR were positively correlated with FAZ contour injury(P<0.05),while negatively correlated with LMR(P<0.05).NLR and PLR in visual disability group were higher than those in visual improvement group(P<0.05),while LMR was lower than that in visual improvement group(P<0.05).ROC curves analysis showed that area under the curve(AUC)values of NLR,PLR,LMR and combined detection for predicting prognosis of DR were 0.799,0.807,0.812 and 0.959,and their cut-off values were 2.82,139.47 and 3.71,respectively.Conclusion:The levels of NLR,PLR and LMR are all related to FAZ contour injury in DR patients,which can also be applied as auxiliary detection indexes to clinically predict visual improvement in DR patients.关键词
糖尿病视网膜病变/光学相干断层扫描/黄斑中心凹无血管区/视力改善Key words
Diabetic retinopathy/Optical coherence tomography/Foveal avascular zone/Visual improvement分类
医药卫生引用本文复制引用
翟崧淇,杨大勇,王春燕..糖尿病视网膜病变患者NLR、PLR、LMR水平与黄斑中心凹无血管区损伤及预后的关系[J].川北医学院学报,2026,41(6):669-672,4.基金项目
内蒙古自治区自然科学基金项目(2020MS08188) （2020MS08188）
内蒙古医科大学附属医院青年骨干项目计划(2022NYFYFG008) （2022NYFYFG008）
