川北医学院学报2026，Vol.41Issue(6)：689-692,4.DOI:10.3969/j.issn.1005-3697.2026.06.009
NB-UVB光疗法联合盐酸左西替利嗪治疗2型糖尿病皮肤瘙痒症的疗效及对T淋巴细胞亚群的影响
Efficacy of NB-UVB phototherapy combined with levocetirizine hydrochloride for pruritus in type 2 diabetes mellitus and its impacts on peripheral blood T lymphocyte subsets
摘要
Abstract
Objective:To explore the synergistic therapeutic effect and mechanism of narrowband ultraviolet B(NB-UVB)phototherapy combined with levocetirizine hydrochloride in the management of pruritus in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 136 T2DM patients complicated with pruritus were enrolled as research subjects.They were assigned into two groups according to different treatment options,with 68 cases in each group.The monotherapy group received oral levocetirizine hydrochloride alone,whereas the combination group was administered NB-UVB phototherapy plus levocetirizine hydrochloride.Both groups underwent a 4-week treatment course.Before and after the intervention,the pruritus symptom score,skin lesion score,and quality of life score were assessed for all patients.Meanwhile,the levels of peripheral blood T lymphocyte subsets in patients were detected.The overall therapeutic efficacy of the two groups was also compared and analyzed.Results:The total effective rate of the combination group was higher than that of the monotherapy group(P<0.05).After 4 weeks of treatment,the pruritus symptom score and skin lesion score in the combination group were lower than those in the monotherapy group(P<0.05),while the quality of life score was higher in the combination group(P<0.05).In terms of immune indicators,the levels of CD3+,CD4+T lymphocytes and the CD4+/CD8+ratio in peripheral blood in the combination group were higher than those in the monotherapy group(P<0.05).Conclusion:NB-UVB phototherapy combined with levocetirizine hydrochloride can effectively alleviate pruritus symptoms and ameliorate skin lesions in T2DM patients with pruritus.More importantly,this combined regimen can regulate the disordered peripheral blood T lymphocyte subsets,improve the body's immune regulation,and thus achieve a better clinical therapeutic effect than single levocetirizine hydrochloride treatment.关键词
2型糖尿病/皮肤瘙痒/窄谱中波紫外线/盐酸左西替利嗪/T淋巴细胞亚群Key words
Type 2 diabetes mellitus/Diabetic pruritus/Narrowband ultraviolet B/Levocetirizine hydrochloride/T lymphocyte subsets分类
医药卫生引用本文复制引用
宋慧丽,吴晨,郭鹏英,胡淑国..NB-UVB光疗法联合盐酸左西替利嗪治疗2型糖尿病皮肤瘙痒症的疗效及对T淋巴细胞亚群的影响[J].川北医学院学报,2026,41(6):689-692,4.基金项目
河北省卫生健康委员会科研项目(20242274) （20242274）
