淡水渔业2026，Vol.56Issue(3)：12-24,13.
水产品氨基脲内外源性来源残留风险及检测鉴别技术研究
Study on the residue risk of endogenous and exogenous sources of semicarbazide in aquatic products and the detection and identification techniques
摘要
Abstract
Semicarbazide(SEM)serves as the metabolic marker for the banned veterinary drug nitrofurazone(NFZ)in aquatic product safety regulation.However,the presence of endogenous background levels in crusta-ceans and formation induced by processing pose significant challenges for regulatory determination.The physi-cochemical properties and toxicological characteristics of SEM were systematically reviewed,alongside an eluci-dation of the complex sources in aquatic products.Formation pathways were analysed,covering exogenous con-ditions such as water pollution and illegal drug use,endogenous mechanisms involving crustacean metabolism,and reactions with disinfectants or additives during processing.Based on a comprehensive survey of SEM resi-due status,dietary intake risks were evaluated using the Margin of Exposure(MOE)approach.To address the"false positive"regulatory dilemma,advanced technologies for differentiating endogenous from exogenous SEM were critically evaluated,including source tracing via Compound-Specific Nitrogen Stable Isotope Ratio Analysis(NSIRA),confirmation using the specific structural marker 5-nitro-2-furaldehyde,and novel non-derivatisati-on/non-hydrolysis detection strategies based on Hydrophilic Interaction Liquid Chromatography(HILIC).Fi-nally,perspectives on constructing a multi-dimensional precision traceability system and optimising current limit standards are proposed to provide a scientific basis for balancing aquatic product safety and international trade facilitation.关键词
水产品/氨基脲/产生机理/风险评估/内源性鉴别Key words
aquatic product/semicarbazide/formation mechanisms/risk assessment/endogenous identification分类
农业科技引用本文复制引用
李兆新,王清燕,邢丽红,孙晓杰,丁环,张俊杰,郄烁,李昕龙,金安琪..水产品氨基脲内外源性来源残留风险及检测鉴别技术研究[J].淡水渔业,2026,56(3):12-24,13.基金项目
中国水产科学研究院黄海水产研究所基本科研业务费项目(20603022026026) （20603022026026）
