动物医学进展2026，Vol.47Issue(6)：38-46,9.
郁金散改良组方对鸡大肠埃希氏菌腹泻模型的治疗效果评价
Evaluation of Therapeutic Effect of Yujin Powder Modified Formula on Chicken E.coli Diarrhea Model
摘要
Abstract
In order to determine the therapeutic effect and dosage of Yujin SAN Modified Formulaon chicken E.coli diarrhea.14 d Luhua chickens were divided into blank control group(Ⅰ),model control group(Ⅱ),1/3,1/2,1,2,3(Ⅲ、Ⅳ、Ⅴ、Ⅵ、Ⅶ)times TCV dose groups and flufenicol group(Ⅷ).In addition to Ⅰ,chickens in each group were treated with antibiotics and given Escherichia coli O78 to establish diarrhea model,and were treated with TCV,flufenicol and normal saline at different doses for 5 days(observation for 3 days)to determine the efficacy.Select Ⅳ,Ⅴ,Ⅵ,Ⅱ and Ⅷ test group chickens,serum biochemical in-dexes,cytokine content,liver pathology and intestinal changes were measured.The results demonstrated af-ter treatment,the clinical symptoms of fever,mental depression,diarrhea and anal paste of chickens in the drug group were significantly improved,and there was no recurrence during the observation period.Com-pared with Ⅱ and Ⅷ,the average daily gain of V was significantly increased,and the ratio of feed to gain was significantly decreased(P＜0.05).The cure rate and total effective rate of Ⅳ,Ⅴ and Ⅵ groups were significantly increased(P＜0.05),but there was no difference among groups(P＞0.05).The contents of ALT,AST,IL-6 and TNF-α in serum were significantly decreased,while the contents of ALB and IL-10 were significantly increased(P＜0.05).The indexes of heart,liver and spleen in Ⅴ and Ⅵ groups were sig-nificantly decreased,while bursa of Fabricius index was significantly increased(P＜0.05).The pathological injury of liver tissue was significantly improved in all drug groups.In addition,duodenal chow-to-crypto ra-tio and Escherichia coli load in Ⅴ group were significantly lower than those in Ⅱ group(P＜0.01),and significantly lower than those in Ⅷ group(P＜0.05).The result shows that TCV can effectively treat chicken Escherichia coli diarrhea,improve growth performance,tissue damage and inhibit pathogen coloni-zation.According to the comprehensive analysis of efficacy and cost,2.7 g/kg is recommended as the opti-mal dose.关键词
中药复方/鸡/大肠埃希氏菌/腹泻/疗效Key words
Chinese medicine compound/Chicken/E.coli/Diarrhea/Curative effect分类
农业科技引用本文复制引用
张国林,张景艳,李建喜,唐茜,柴晓梦,张宏,陈富斌,张洺溪,陈海瑜,王学智,张勇..郁金散改良组方对鸡大肠埃希氏菌腹泻模型的治疗效果评价[J].动物医学进展,2026,47(6):38-46,9.基金项目
甘肃省创新引导计划项目(22CX8NA013) （22CX8NA013）
十四五乡村产业专项项目子课题(2022YFD1602204) （2022YFD1602204）
中央引导地方科技发展资金项目子课题(24ZYQK001) （24ZYQK001）
农业农村部中兽医生物学重点实验室开放基金项目(NYX2024013) （NYX2024013）
中央级公益性基本科研业务费项目(1610322026034) （1610322026034）
