辐射防护2026，Vol.46Issue(3)：234-242,9.DOI:10.27045/j.1000-8187.202603006
基于元素分析仪的生物基体碳含量分析
Determination of carbon content in biological samples using elemental analyzer
摘要
Abstract
14C,a long-lived radionuclide,is widely used as a tracer in human mass balance and pharmacokinetic studies.The 14C/12C ratio in biological samples was measured by a high-sensitivity accelerator mass spectrometer,and the carbon content in the samples was analyzed by the elemental analyzer,which can reflect the content of 14C markers in different biological matrices(including serum,plasma,whole blood and urine).In this paper,a high-precision measurement program for carbon content in biological samples was established by studying the key parameters of carbon content in biological samples measured by the elemental analyzer.The results show that the relative standard deviation of carbon content measurement in various biological samples is less than 5%when the sample sampling amount is 60～100 mg and the oxygen flow is≥75 mL.It can be applied to the high-precision analysis of carbon content in different types of biological samples,and provides an effective analytical method for the accurate calculation of 14C activity in subsequent samples.关键词
碳含量/生物样品/元素分析仪Key words
carbon content/biological samples/elemental analyzer分类
资源环境引用本文复制引用
黄慧,原妮,安全,罗茂益,王志鹏,郭媛媛,王远飞..基于元素分析仪的生物基体碳含量分析[J].辐射防护,2026,46(3):234-242,9.基金项目
山西省重点研发计划项目(202102130501022) （202102130501022）
中国辐射防护研究院创新团队项目(YC22000702). （YC22000702）
