分析测试学报2026，Vol.45Issue(6)：1174-1187,14.DOI:10.12452/j.fxcsxb.26021901
中药大品种二次开发关键技术研究进展及相关思考:以血府逐瘀制剂为例
Research Progress and Related Thoughts on Key Technologies for the Secondary Development of Large Varieties of Traditional Chinese Medicine:A Case Study of Xuefu Zhuyu Preparations
摘要
Abstract
Traditional Chinese medicine preparations still have potential safety hazards due to com-plex components,vague pharmacodynamic material basis,insufficient quality controllability and un-clear mechanism of action,which affect their popularization and internationalization.In response to the above problems,the field of traditional Chinese medicine has gradually formed a systematic re-development idea with the core concept of"new use of old drugs and renewal of classics",and pro-moted the in-depth excavation and re-evaluation of large varieties of traditional Chinese medicine.With the in-depth application of artificial intelligence,process analysis technology,network pharma-cology,mass spectrometry technology and quality by design concept in the research of traditional Chi-nese medicine,the modernization and scientific development of large varieties of traditional Chinese medicine ushered in new opportunities.In this paper,Xuefu Zhuyu preparation,a typical large vari-ety of traditional Chinese medicine for promoting blood circulation and removing blood stasis,was taken as the research object.For the first time,the key technical system involved in its secondary de-velopment was systematically sorted out,including five dimensions:quality control,mechanism analysis,clear efficacy,efficacy improvement and international recognition.At the same time,combined with the application examples of artificial intelligence and large language model,the rele-vant technical paths were optimized and the common experience was refined to explore the future de-velopment direction of large varieties of traditional Chinese medicine,so as to provide a reference paradigm for the modernization and upgrading of similar varieties.关键词
中药大品种/血府逐瘀制剂/二次开发/过程分析技术/人工智能Key words
large varieties of traditional Chinese medicine/Xuefu Zhuyu preparations/secondary development/process analytical technology/artificial intelligence分类
化学化工引用本文复制引用
沙鑫,常淏,宋纹,余河水,李正,李文龙..中药大品种二次开发关键技术研究进展及相关思考:以血府逐瘀制剂为例[J].分析测试学报,2026,45(6):1174-1187,14.基金项目
国家重点研发计划(2023YFC3504502) （2023YFC3504502）
现代中医药海河实验室-天津宏仁堂药业有限公司合作项目(XMH2022004)资助 （XMH2022004）
