分析化学2026，Vol.54Issue(5)：761-776,16.DOI:10.19756/j.issn.0253-3820.251306
镧系近红外二区发光材料在生物传感与诊疗中的应用进展
Application Progress of Lanthanide Near-Infrared Ⅱ Luminescent Materials in Biosensing and Diagnosis and Therapy
摘要
Abstract
With the improvement of people's living standards,the demand for refined health management is increasingly growing,putting forward higher requirements for early diagnosis and precise treatment of diseases.Lanthanide-based near-infrared Ⅱ region(NIR-Ⅱ)luminescent materials,with advantages of narrow-band emission,high tissue penetration,low photon scattering,and minimal autofluorescence interference,have overcome the limitations of traditional optical materials,and have demonstrated significant value in the fields of biological detection and disease theranostics,emerging as key candidate materials for precision medicine.In this review,the application progress of lanthanide NIR-Ⅱ luminescent materials in biological detection and disease management were systematically summarized,covering their roles in biosensing,bioimaging(Including structural imaging,functional imaging,and multimodal imaging),as well as tumor therapy(Imaging-guided surgery and theranostics).Additionally,the limitations and challenges associated with their biomedical applications were discussed.By elaborating on these aspects,this paper aimed to provide valuable insights and references for the material design optimization and clinical translation of lanthanide NIR-Ⅱ luminescent materials,thereby advancing the fields of biological detection and disease treatment.关键词
镧系近红外二区发光/生物传感/成像/肿瘤诊断/诊疗一体化/评述Key words
Lanthanide near-infrared Ⅱ luminescent/Biosensing/Imaging/Tumor diagnosis/Theranostics/Review引用本文复制引用
彭琳,廖彬,王特,张玲玲,崔剑桥,汪啸..镧系近红外二区发光材料在生物传感与诊疗中的应用进展[J].分析化学,2026,54(5):761-776,16.基金项目
湖南省自然科学基金项目(No.2025JJ90206)和中国博士后科学基金项目(No.E31S2008)资助. Supported by the Natural Science Foundation of Hunan Province(No.2025JJ90206)and the China Postdoctoral Science Foundation(No.E31S2008). （No.2025JJ90206）
