赣南医科大学学报2026，Vol.46Issue(5)：395-409,15.DOI:10.3969/j.issn.2097-7174.2026.05.001
基于生物信息学探索RPS14作为癌症多功能生物标志物的价值:对诊断、预后及免疫治疗反应的启示
Bioinformatics-based exploration of RPS14 as a multifaceted biomarker in cancer:implications for diagnosis,prognosis,and immunotherapeutic response
彭博 1赵和圆 2杨钰 3邵书伦 1何良梅 4赖姨梅 5李玉梅1
作者信息
- 1. 赣南医科大学基础医学院
- 2. 赣南医科大学医学信息工程学院
- 3. 赣南医科大学第一临床医学院
- 4. 赣南医科大学第一附属医院消化内科
- 5. 赣南医科大学第一附属医院病理科,江西 赣州 341000
- 折叠
摘要
Abstract
Objective:To explore the differential expression changes of ribosomal protein S14(RPS14)in pan-cancer,and to analyze its correlation with the clinical characteristics,survival prognosis,immune infiltration,drug sensitivity of various cancer types,as well as its potential role and regulatory mechanism in cancer.Methods:RPS14 mRNA and protein expression levels were analyzed using data from the cancer genome atlas and clinical proteomic tumor analysis consortium.Their associations with tumor stage and patient prognosis were evaluated across cancer types.RPS14 interacting genes were obtained from the search tool for the retrieval of interacting genes/proteins database and subjected to gene ontology and kyoto encyclopedia of genes and genomes enrichment analyses.Potential transcription factors regulating RPS14 were predicted using human transcription factor target database and related databases.The immunomodulatory role of RPS14 was assessed using tumor immune estimation resource,version 2.0.The gene set cancer analysis database was used to examine the relationships among RPS14 expression,therapeutic response and drug sensitivity.Results:RPS14 showed dysregulated expression in multiple cancer types,especially upregulated in cholangiocarcinoma,colon adenocarcinoma,glioblastoma multiforme and liver hepatocellular carcinoma,and downregulated in kidney renal clear cell carcinoma and prostate adenocarcinoma.Aberrant RPS14 expression was closely associated with shorter overall survival in patients with LIHC.These findings suggest that RPS14 may serve as a diagnostic and prognostic marker,particularly in liver hepatocellular carcinoma.Functional enrichment analysis showed that RPS14 related genes were mainly involved in ribosome-associated pathways and were linked to sensitivity to several anticancer drugs.In addition,RPS14 was correlated with multiple immune related genes,suggesting a potential association with tumor infiltration of CD8+T cells and other immune cells.Conclusion:RPS14 is involved in cancer progression,functional regulation,prognosis,the tumor microenvironment,therapeutic potential,and drug sensitivity prediction.It may serve as a promising biomarker for predicting cancer outcomes and as a potential therapeutic target.关键词
核糖体蛋白S14/泛癌生物信息学分析/癌症生物标志物/预后/免疫浸润Key words
Ribosomal protein S14/Pan-cancer bioinformatics analysis/Cancer biomarker/Prognosis/Immune infiltration分类
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彭博,赵和圆,杨钰,邵书伦,何良梅,赖姨梅,李玉梅..基于生物信息学探索RPS14作为癌症多功能生物标志物的价值:对诊断、预后及免疫治疗反应的启示[J].赣南医科大学学报,2026,46(5):395-409,15.
