赣南医科大学学报2026，Vol.46Issue(5)：460-468,9.DOI:10.3969/j.issn.2097-7174.2026.05.010
病理性心肌肥厚动物模型的研究进展
Advances in disease modeling of pathological cardiac hypertrophy
摘要
Abstract
Pathological cardiac hypertrophy(PCH)is a crucial pathological process in the development of heart failure from a variety of cardiovascular disorders.To elucidate its pathogenesis and explore effective therapeutic strategies,worldwide researchers have established multiple animal models of PCH across different species,including mice,rats,rabbits,cats,dogs,sheep,and pigs.Despite significant progress in existing research,systematic comparative studies of different modeling methods remain scarce in large animals with genetic structures more closely aligned with humans.This paper compares the benefits and drawbacks of various model animals while methodically reviewing the most recent developments in PCH animal models.It focuses on the principles,phenotypic traits,and applicability of various modeling approaches.Overall,animal models of PCH show distinct strengths across different pathogenic mechanisms and research settings.However,in large-animal models,systematic comparative studies and unified evaluation criteria are still lacking,which limits their practical application to some extent.Future work should place greater emphasis on phenotype-oriented model design and on developing large-animal models that can stably reproduce specific disease stages to promote their clinical translation.关键词
左心室心肌肥厚/动物疾病模型/主动脉缩窄/动静脉造瘘/心力衰竭/心室重塑Key words
Left ventricular hypertrophy/Animal disease models/Aortic coarctation/Arteriovenous fistula/Heart failure/Ventricular remodeling分类
医药卫生引用本文复制引用
贾嗣洲,万娟,丁浩,毛兆祺,田松,王周祥,陈英琼,陈芸,胡曼丽,张鑫..病理性心肌肥厚动物模型的研究进展[J].赣南医科大学学报,2026,46(5):460-468,9.基金项目
国家自然科学基金青年项目(82200327,82300456) （82200327,82300456）
江西省重点研发计划项目(20243BCC31006) （20243BCC31006）
江西省重大科技成果熟化与工程化研究项目(20232AEI92008) （20232AEI92008）
赣州市章贡区科技计划项目(2024RC01) （2024RC01）
