国际生殖健康/计划生育杂志2026，Vol.45Issue(3)：230-235,6.DOI:10.12280/gjszjk.20260032
驱动蛋白家族成员18B在女性生殖功能中作用机制的研究进展
Research Progress on the Mechanism of KIF18B in Female Reproductive Function
王薇 1戴柏 2沙日娜 3托娅2
作者信息
- 1. 010050 呼和浩特,内蒙古医科大学
- 2. 内蒙古医科大学附属医院生殖医学中心
- 3. 内蒙古医科大学附属医院病理科
- 折叠
摘要
Abstract
The maintenance and decline of female fertility is a complex physiological process.Kinesin family member 18B(KIF18B)maintains the genome stability by regulating spindle microtubule dynamics to ensure the accurate alignment and segregation of chromosomes.Given the critical role of KIF18B in cell division,its potential functions in the female reproductive system have also attracted attention.KIF18B may participate in oocyte maturation by affecting meiotic spindle assembly,and its association with signaling pathways such as phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin complex 1(PI3K/Akt/mTORC1)suggests a potential role in primordial follicle activation and ovarian aging.In addition,the regulation of KIF18B on microtubule dynamics implies the involvement in endometrial structural remodeling.As an upstream regulatory node of the Wnt/β-catenin pathway,KIF18B influences the establishment of endometrial receptivity.Dysfunction of KIF18B,including the increased rate of oocyte aneuploidy,the diminished ovarian reserve,and the reduced endometrial receptivity could further increase the risk of adverse pregnancy outcomes.This review summarizes the molecular mechanisms and functions of KIF18B,elucidates its regulatory roles in key reproductive processes and the potential links between its dysfunction and poor pregnancy outcomes,and discusses its prospective value as a biomarker for assessing fertility.关键词
细胞分裂/非整倍性/胚胎植入/妊娠结局/驱动蛋白家族成员18BKey words
Cell division/Aneuploidy/Embryo implantation/Pregnancy outcome/Kinesin family member 18B引用本文复制引用
王薇,戴柏,沙日娜,托娅..驱动蛋白家族成员18B在女性生殖功能中作用机制的研究进展[J].国际生殖健康/计划生育杂志,2026,45(3):230-235,6.
