保健医学研究与实践2026，Vol.23Issue(3)：62-68,7.DOI:10.11986/j.issn.1673-873X.2026.03.10
血清RIP3、TLR9水平在预测老年重症肺炎患者预后中的临床价值
Clinical value of serum RIP3 and TLR9 levels in predicting the prognosis of elderly patients with severe pneumonia
摘要
Abstract
Objective To investigate the clinical value of serum receptorinteracting protein 3(RIP3)and Tolllike receptor 9(TLR9)levels in predicting the prognosis of elderly patients with severe pneumonia.Methods A total of 228 elderly pa-tients with severe pneumonia admitted to Beijing Daxing District People's Hospital from October 2022 to December 2024 were selected and assigned to a good prognosis group(n=170)and a poor prognosis group(n=58)according to their dis-charge outcomes.The serum RIP3 and TLR9 levels and baseline data were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum RIP3 and TLR9 levels for the prog-nosis of elderly patients with severe pneumonia,and multivariate logistic stepwise regression analysis was used to identify the influencing factors for prognosis.Results The serum RIP3 and TLR9 levels in the poor prognosis group were signifi-cantly higher than those in the good prognosis group(P<0.05).ROC curve analysis showed that the AUCs of serum RIP3 and TLR9 for predicting prognosis were 0.716(95%CI:0.671-0.766)and 0.829(95%CI:0.784-0.879),respective-ly.The AUC of the combined detection was 0.902(95%CI:0.857-0.952),which was higher than that of serum RIP3 or TLR9 alone(Z=8.162,10.328;P<0.05).The Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,Multiple Organ Dysfunction Syndrome(MODS)score,and the proportions of patients with a history of alcohol con-sumption,mechanical ventilation,and indwelling catheter in the poor prognosis group were higher than those in the good prognosis group,with statistically significant differences(P<0.05).Multivariate analysis showed that APACHE Ⅱ score(OR=1.998,95%CI:1.179-3.385),MODS score(OR=1.964,95%CI:1.087-3.550),serum RIP3(OR=3.102,95%CI:1.802-5.338),and serum TLR9(OR=2.956,95%CI:1.880-4.650)were influencing factors for the prog-nosis of elderly patients with severe pneumonia(P<0.05).Conclusion Elevated serum RIP3 and TLR9 levels are closely correlated with poor prognosis in elderly patients with severe pneumonia,and their combined detection can improve the pre-dictive efficacy for adverse outcomes,demonstrating important clinical value.关键词
重症肺炎/老年患者/受体相互作用蛋白3/Toll样受体9/预后/预测效能Key words
Severe pneumonia/Elderly patients/Receptorinteracting protein 3/Tolllike receptor 9/Prognosis/Predictive ef-ficacy分类
医药卫生引用本文复制引用
紫士怡,高原,杨佳靓,于伟,张燕,季家希,信维娜,王雪琳..血清RIP3、TLR9水平在预测老年重症肺炎患者预后中的临床价值[J].保健医学研究与实践,2026,23(3):62-68,7.基金项目
首都卫生发展科研专项项目(首发2022-3-7122). （首发2022-3-7122）
