化学试剂2026，Vol.48Issue(6)：62-67,6.DOI:10.13822/j.cnki.hxsj.2026.0090
席夫碱探针可视化淬灭识别铜离子和铁离子
Quenching of Schiff Base Probe for Recognition of Copper and Iron Ions
摘要
Abstract
To achieve rapid and specific detection of Cu2+and Fe3+in complex environments,we designed and synthesized a novel Schiff base fluorescent probe based on 2-furancarboxyhydrazide.Target probe 1 was successfully obtained by introducing 4-dimethylaminocinnamaldehyde into the amino site of 2-furancarboxaldehyde hydrazide,and its structure was comprehensively characterized using 1 H and 13 C nuclear magnetic resonance(NMR)spectroscopy and infrared spectroscopy.The recognition performance of probe 1 for various metal ions was investigated using UV-visible absorption spectroscopy and fluorescence spectroscopy.The results showed that in a system with multiple cations,probe 1 achieved rapid and highly sensitive quenching recognition of Cu2+and Fe3+with good selectivity.Job's plot indicated that the complexation ratio of probe 1 with both ions was 1∶1.By combining NMR titration with density functional theory calculations,the binding sites of the probe and ions,as well as the fluorescence quenching mechanism,were elucidated.Based on this,probe 1 was combined with a portable 365 nm ultraviolet lamp to develop a simple strip-based platform for ion sensing.This platform enables the rapid on-site identification of Cu2+and Fe3+by observing the degree of fluorescence quenching with the naked eye.In summary,the novel Schiff base fluorescent probe obtained in this study exhibits high selectivity and sensitivity towards Cu2+and Fe3+.Combined with a portable test strip platform,the probe provides a feasible solution for rapid on-site detection of metal ions.关键词
席夫碱/2-呋喃甲酰肼/荧光探针/金属离子/机制研究Key words
Schiff base/2-furoic hydrazide/fluorescent probe/metal ion/mechanism分类
化学化工引用本文复制引用
曹旭旭,郑国彪,郭素琴,李杰森,李红光,刘文锋..席夫碱探针可视化淬灭识别铜离子和铁离子[J].化学试剂,2026,48(6):62-67,6.基金项目
NLRP3抑制剂的合成与抗AD活性研究项目(S202411349111). （S202411349111）
