杭州师范大学学报（自然科学版）2026，Vol.25Issue(3)：257-267,11.DOI:10.19926/j.cnki.issn.1674-232X.2025.01.222
液-液相分离的发生机制及其在肿瘤进展中的关键作用
Mechanism of liquid-liquid phase separation and its key role in tumor progression
摘要
Abstract
Liquid-liquid phase separation(LLPS)can drive the spontaneous aggregation of biomacromolecules such as proteins and nucleic acids within cells,forming biomolecular condensate(BMC)with liquid-like properties,also known as membrane-less organelle(MLO).Studies have found that the formation,regulation,and dysregulation of LLPS of key proteins are closely related to processes such as tumor initiation,progression,metastasis,and angiogenesis.This article systematically reviews the mechanism of LLPS and discusses its role at different stages of tumor development,aiming to provide a theoretical basis for treating malignant tumors by targeting the LLPS of key proteins.关键词
无膜细胞器/液-液相分离/内在无序区域/肿瘤Key words
membrane-less organelle/liquid-liquid phase separation/intrinsically disordered region/tumor分类
生物科学引用本文复制引用
陈宣儒,王天卓,林佳杰,刘喆..液-液相分离的发生机制及其在肿瘤进展中的关键作用[J].杭州师范大学学报（自然科学版）,2026,25(3):257-267,11.基金项目
国家自然科学基金青年基金项目(82303403) （82303403）
浙江省自然科学基金探索项目(LMS26H160021) （LMS26H160021）
