杭州师范大学学报（自然科学版）2026，Vol.25Issue(3)：268-275,8.DOI:10.19926/j.cnki.issn.1674-232X.2024.11.263
伊立替康微乳的制备及体外释药评价
Preparation and in vitro release evaluation of irinotecan microemulsion
摘要
Abstract
The formulation components of irinotecan blank microemulsion were screened using the pseudo-ternary phase diagram method.The optimal formulation was determined based on evaluation indices including mean particle size,polydispersity index(PDI),and drug loading capacity,and the irinotecan-loaded microemulsion was successfully prepared.The pharmaceutical characteristics and in vitro drug release behavior of the microemulsion were investigated.The results showed that when 1944-CS was used as the oil phase,RH60 as the emulsifier,PEG300 as the co-emulsifier,and the mass ratio(Km)of the emulsifier to the co-emulsifier was 3∶1,the obtained microemulsion exhibited the largest area and the most stable properties.When the drug loading of irinotecan was 0.5％of the total system mass,the prepared microemulsion appeared spherical with uniform dispersion,a mean particle size of(78.12±2.42)nm,a PDI of 0.342±0.031,a Zeta potential of(-1.93±0.51)mV,and demonstrated good centrifugal stability and temporal stability.The 24-hour cumulative drug release rate was significantly lower than that of the free drug.Thus,the prepared irinotecan microemulsion possesses good stability and sustained-release properties,suggesting its potential as a feasible pharmaceutical formulation for the clinical anti-tumor therapy of irinotecan.关键词
伊立替康/微乳/伪三元相图Key words
irinotecan/microemulsion/pseudo-ternary phase diagram分类
化学化工引用本文复制引用
卜晓阳,沈学彬,王艺萍,黄瑞,陈云艳..伊立替康微乳的制备及体外释药评价[J].杭州师范大学学报（自然科学版）,2026,25(3):268-275,8.基金项目
安徽省自然科学基金项目(2108085QH370) （2108085QH370）
国家科学中心大健康研究院新安医学与中医药现代化研究所"揭榜挂帅"项目(2023CXMMTCM023) （2023CXMMTCM023）
安徽省大学生创新创业训练项目(S202010368065) （S202010368065）
安徽省分子基材料省级实验室开放基金项目(fzj22016) （fzj22016）
