吉林中医药2026，Vol.46Issue(6)：677-681,5.DOI:10.13463/j.cnki.jlzyy.2026.06.001
基于"因瘀致毒,瘀毒致变"探讨心力衰竭合并利尿剂抵抗的辨治
Treatment of heart failure complicated with diuretic resistance based on the theory of toxins caused by blood stasis and lesions induced by blood stasis and toxins
摘要
Abstract
Heart failure combined with diuretic resistance falls within the category of"diseases caused by blood stasis and toxins",and its core pathogenesis evolution features"toxins caused by blood stasis and lesions caused by blood stasis and toxins".Traditional Chinese medicine can play a role in improving heart failure complicated with diuretic resistance through anti-inflammation,antioxidant and vascular endothelial function regulation and other pathways.Based on the theory of blood stasis and toxins,combined with modern medical research,this paper systematically explores the interaction between blood stasis and toxins and factors such as water dampness,qi stagnation,and yang deficiency,as well as the dynamic pathogenesis in the progression of this disease.It states that blood stasis blocks the heart meridian,which over time transforms into heat and generates toxins.The toxins and blood stasis accumulate and block sanjiao,hindering the distribution of qi,blood and body fluids,which leads to a poor transformation of body fluids and persistent edema,thereby aggravating heart failure and causing a resistance to diuretics.While detoxification and promoting blood circulation count as the fundamental treatment methods for this disease,treatment methods are proposed in this paper that take into account benefiting qi and warming yang,dispersing the liver and regulating qi,strengthening the spleen and promoting diuresis,as well as using insect drugs to unblock meridians and detoxify based on different concurrent syndromes.This study underscores the therapeutic principle of"removing blood stasis and detoxifying,strengthening and consolidating the body's resistance",aiming to improve cardiac function and diuretic sensitivity by harmonizing qi and blood,unblocking meridians,detoxifying and promoting diuresis.关键词
因瘀致毒/瘀毒致变/心力衰竭/利尿剂抵抗/活血解毒/疏肝理气/健脾利水Key words
toxins caused by blood stasis/lesion induced by blood stasis and toxins/heart failure/diuretic resistance/promoting blood circulation and detoxication/dispersing the liver and regulating qi/invigorating the spleen for diuresis分类
医药卫生引用本文复制引用
周莉君,王昕玥,李彤,王秋涛,杨圣洁,吴敏..基于"因瘀致毒,瘀毒致变"探讨心力衰竭合并利尿剂抵抗的辨治[J].吉林中医药,2026,46(6):677-681,5.基金项目
国家自然科学基金项目(82074254,82374281) （82074254,82374281）
北京市自然科学基金项目(7172185) （7172185）
中国中医科学院科技创新工程项目(CI2021A01413) （CI2021A01413）
第五批中医临床优秀人才研修项目(国中医药人才函[2022]1号) （国中医药人才函[2022]1号）
北京市中医药科技发展资金项目(BJZYYB-2023-73) （BJZYYB-2023-73）
首都卫生发展科研专项项目(首发2024-2-4154) （首发2024-2-4154）
