吉林中医药2026，Vol.46Issue(6)：682-686,5.DOI:10.13463/j.cnki.jlzyy.2026.06.002
基于"肠道菌群-免疫轴"探讨从脾论治自身免疫性甲状腺炎
Treatment of autoimmune thyroiditis from the perspective of"gut microbiota-immunity axis"based on the spleen theory
摘要
Abstract
Autoimmune thyroiditis is a common disease of the endocrine system,with its incidence rate increasing year by year,and its accompanying symptoms seriously affecting the quality of life of patients and their families.It has been found that the gut microbiota has a close relationship with the spleen,and the balance of the gut microbiota is related to the normalization of the spleen's function.Disordered gut microbiota as a risk factor can directly or indirectly cause autoimmune thyroiditis through its metabolites and immune mechanism.The spleen plays a regulatory role in autoimmune thyroiditis,gut microbiota and immune response.Therefore,this article discusses the treatment of autoimmune thyroiditis from the perspective of"gut microbiota-immunity axis"based on the spleen theory.It is argued that the method of tonifying qi and strengthening the spleen can improve the disorder of gut microbiota,reduce the immune-inflammatory reaction,and treat autoimmune thyroiditis.关键词
自身免疫性甲状腺炎/肠道菌群/免疫/从脾论治Key words
autoimmune thyroiditis/gut microbiota/immunity/spleen-based treatment分类
医药卫生引用本文复制引用
王兰亭,翟钊晗,陈怡然,鞠首信,陈雪莹,高天舒,王智民..基于"肠道菌群-免疫轴"探讨从脾论治自身免疫性甲状腺炎[J].吉林中医药,2026,46(6):682-686,5.基金项目
国家自然科学基金青年项目(82104805) （82104805）
辽宁省科技计划联合计划项目(2023-MSLH-177,2023-MSLH-197) （2023-MSLH-177,2023-MSLH-197）
辽宁省教育厅面上项目(LJKZ0881) （LJKZ0881）
辽宁省教育厅高校基本科研项目储备项目(2024-JYTCB-067) （2024-JYTCB-067）
