检验医学与临床2026，Vol.23Issue(11)：1486-1491,6.DOI:10.3969/j.issn.1672-9455.2026.11.008
等离子射频消融术联合口服盐杜仲颗粒治疗腰椎间盘突出症的临床疗效
Clinical efficacy of plasma radiofrequency ablation combined with oral salt Eucommia granules in the treatment of lumbar disc herniation
摘要
Abstract
Objective To investigate the clinical efficacy of plasma radiofrequency ablation(RFA)com-bined with oral salt eucommia granules in the treatment of lumbar disc herniation(LDH).Methods A total of 208 patients with LDH admitted to this hospital from January 2022 to December 2024 were selected as the research objects,and they were divided into radiofrequency group(103 cases)and combined particle group(105 cases)by random number table method.The radiofrequency group was treated with low temperature RFA,and the combined granule group was treated with salt Eucommia granule on the basis of the radiofre-quency group.The clinical efficacy,pain degree,lumbar function and serological indexes[β-endorphin(β-EP),matrix metalloproteinase-3(MMP-3),prostaglandin E2(PGE2)]levels were compared between the two groups.The adverse reactions of the two groups during treatment were recorded.Results The total effective rate of the combined particle group was 98.10%,which was higher than 86.41%of the radiofrequency group,and the difference was statistically significant(P<0.05).After treatment,the visual analogue scale(VAS)score,serum MMP-3 and PGE2 levels of the two groups were lower than those before treatment,and the ser-um β-EP level was higher than that before treatment.The VAS score,serum MMP-3 and PGE2 levels of the combined granule group were lower than those of the radiofrequency group,and the serum β-EP level was higher than that of the radiofrequency group,the absolute value of VAS score and the difference of serum MMP-3,PGE2 and β-EP levels in the combined granule group were greater than those in the radiofrequency group,and the differences were statistically significant(P<0.05).After treatment,the serum levels of β-EP,subjective symptoms,clinical signs,JOA score and total score of activity limitation in both groups were higher than those before treatment,and those in the combined granule group were higher than those in the radiofre-quency group.The absolute values of the differences in the levels of β-EP,subjective symptoms,clinical signs,JOA score and total score of activity limitation in the combined granule group were greater than those in the radiofrequency group,the differences were statistically significant(P<0.05).During the treatment,no ad-verse reactions such as rashes or itching occurred in the two groups.Conclusion RFA combined with salt eu-commia granules can effectively reduce the patients'low back pain and leg pain,improve the patients'lumbar function,optimize MMP-3,PGE2,β-EP index levels,and improve the clinical efficacy.关键词
腰椎间盘突出症/等离子射频消融术/盐杜仲颗粒/基质金属蛋白酶-3/前列腺素E2/β-内啡肽Key words
lumbar disc herniation/plasma radiofrequency ablation/salt eucommia granules/matrix metalloproteinase-3/prostaglandin E2/β-endorphin分类
医药卫生引用本文复制引用
陈明亮,林晨曦,宫雪晴..等离子射频消融术联合口服盐杜仲颗粒治疗腰椎间盘突出症的临床疗效[J].检验医学与临床,2026,23(11):1486-1491,6.基金项目
江苏省卫生健康委员会医学科研项目(Z2023120). （Z2023120）
