临床口腔医学杂志2026，Vol.42Issue(5)：265-269,5.DOI:10.3969/j.issn.1003-1634.2026.05.003
CGF与Bio-Oss不同比例复合物引导颌骨再生的临床效果评价
Clinical evaluation of different proportions of CGF and Bio-Oss composites in guiding jawbone regeneration
摘要
Abstract
Objective:To assess the clinical efficacy of different CGF(concentrated growth factor)and Bio-Oss bone meal composite ratios in guiding jawbone regeneration and determine the optimal ratio.Methods:Forty patients with jawbone cysts were divided into 4 groups.Composite materials were prepared with CGF and Bio-Oss at mass ratios of 1∶1(group A),2∶1(group B),4∶1(group C),and pure CGF(control group D),then implanted into bone cavities for regeneration.Follow-ups included imaging examinations and assessment of postoperative inflammation/swelling.Bone regeneration was evaluated at 3 and 6 months postoperatively.Results:At all observation time points,the average gray value of the residual bone cavity after jaw cyst surgery,bone regeneration in groups A,B,and C was significantly better than in group D(P<0.05).At 6 months,group B had significantly higher values than A,C(P<0.05).For inflammation/swelling,group B and C had lower indices than group A(P<0.05),group C lower than group B(P>0.05).Histological evaluations at 6 months postoperatively demon-strated nearly complete resorption of Bio-Oss bone graft particles,robust neo-osteogenesis and osteocyte formation,as well as dense,well-organized bone trabeculae with high osteogenic maturity.Conclusion:A CGF-to-Bio-Oss mass ratio of 2∶1 opti-mizes jawbone regeneration at 6 months,enhancing bone repair and accelerating patient recovery.关键词
浓缩生长因子/混合比例/颌骨囊肿/骨再生Key words
Concentrated growth factors/Mixing ratio/Jawbone cyst/Bone regeneration分类
医药卫生引用本文复制引用
单志暄,林杰,夏华宽,齐李平,郭子源,龚飞飞..CGF与Bio-Oss不同比例复合物引导颌骨再生的临床效果评价[J].临床口腔医学杂志,2026,42(5):265-269,5.基金项目
2024年安徽省卫生健康科研项目(AHWJ2024Ab0071) （AHWJ2024Ab0071）
蚌埠医科大学研究生科研创新计划项目(Byycx24108) （Byycx24108）
