临床口腔医学杂志2026，Vol.42Issue(5)：274-279,6.DOI:10.3969/j.issn.1003-1634.2026.05.005
慢性牙周炎患者血清TIM3、ROCK1、IRF4水平与牙周临床指标的关系分析
Analysis of the relationship between serum TIM3,ROCK1,IRF4 levels and periodontal clinical indicators in patients with chronic periodontitis
摘要
Abstract
Objective:To explore the relationship between serum T-cell immunoglobulin and mucin domain-contai-ning molecule 3(TIM3),rho-associated coiled-coil containing protein kinase 1(ROCK1),interferon regulatory factor 4(IRF4)levels and periodontal clinical indicators in patients with chronic periodontitis(CP).Methods:Totally 216 CP pa-tients were selected as the research subjects(CP group)(mild group 94 cases,moderate-severe group 122 cases)based on periodontal clinical indicators.Additionally,216 healthy adults with oral health were selected as the control group.The ex-pression levels of TIM3,ROCK1 and IRF4 in serum were determined.Pearson correlation was used to analyze the correlations between serum TIM3,ROCK1 and IRF4 levels and periodontal clinical indicators,inflammatory factors in CP patients.Multi-variate Logistic regression analysis was conducted to identify the influencing factors of the severity of the condition in CP pa-tients.Moreover,receiver operating characteristic curve(ROC)was used to analyze the efficiency of serum TIM3,ROCK1,and IRF4 in assessing the severity of the condition in CP patients.Results:The serum TIM3,ROCK1 and IRF4 in the CP group were obviously higher than those in the control group(P<0.05).The periodontal clinical indicators(PLI,SBI,PD,AL)and inflammatory factors(IL-6,IL-17,TNF-α),TIM3,ROCK1,and IRF4 of CP patients in the moderate-severe group were obviously higher than those in the mild group(P<0.05).Serum TIM3,ROCK1 and IRF4 were positively correlated with the clinical indicators of periodontal disease(PLI,SBI,PD,AL)and inflammatory factors(IL-6,IL-17,TNF-α).The elevated ser-um TIM3(OR=4.225),elevated ROCK1(OR=3.605),and elevated IRF4(OR=3.222)were independent risk factors for the development of moderate to severe disease in CP patients(P<0.05).The area under the curve(AUC)for the individual assessment of the severity of CP patients by serum TIM3,ROCK1,and IRF4 were 0.807,0.788,and 0.776 respectively.The AUC for the combined assessment of the three was 0.927,with a sensitivity of 86.07%and a specificity of 91.49%,com-bined assessment was superior to individual assessments(P<0.05).Conclusion:Serum TIM3,ROCK1 and IRF4 in CP pa-tients are elevated,and they are closely related to dental periodontal clinical indicators such as PD,AL and GBI,as well as inflammatory factors.The combined detection of these three indicators has a relatively high efficiency in assessing the condi-tion.关键词
慢性牙周炎/T细胞免疫球蛋白黏蛋白分子3/Rho相关卷曲螺旋蛋白激酶1/干扰素调节因子4/牙周临床指标Key words
Chronic periodontitis/T-cell immunoglobulin and mucin domain-containing molecule 3/Rho-associated coiled-coil kinase 1/Interferon regulatory factor 4/Periodontal clinical indicators分类
医药卫生引用本文复制引用
李梦琦,刘文静,张舒琪,黄育萌,李俊..慢性牙周炎患者血清TIM3、ROCK1、IRF4水平与牙周临床指标的关系分析[J].临床口腔医学杂志,2026,42(5):274-279,6.基金项目
镇江市社会发展指导性科技计划项目(FZ2024054) （FZ2024054）
