Abstract
Objective To investigate the distribution and drug resistance profiles of multidrug-resistant organisms(MDROs)in skin wounds of inpatients in the Department of Dermatology,and to explore corresponding nursing strategies for prevention and control.Methods Clinical data of 149 inpatients with MDRO-infected skin wounds were retrospectively collected from the Hospital of Dermatology,Chinese Academy of Medical Sciences,between January 2020 and April 2025.Data were extracted via the hospital's nosocomial infection management system.Demographics,under-lying dermatoses,pathogen distribution,sampling sites,and antimicrobial susceptibility patterns were analyzed.Results Among the 149 patients,pemphigus(55 cases,36.9％),bullous pem-phigoid(25 cases,16.8％),and mycosis fungoides(13 cases,8.7％)were the most prevalent conditions.A total of 161 MDRO strains were isolated,including 109(67.7％)Gram-positive bacteria,primarily methicillin-resistant Staphylococcus aureus(MRSA),multidrug-resistant Staph-ylococcus epidermidis,and multidrug-resistant Staphylococcus haemolyticus;and 52(32.3％)Gram-negative bacteria,predominantly multidrug-resistant Klebsiella pneumoniae,Escherichia coli,and Proteus mirabilis.The most common sampling sites were the limbs(72 cases,44.7％),fol-lowed by the trunk(55 cases,34.2％)and the head,face,and neck(11 cases,6.8％).MR-SA showed high resistance rates to penicillin(98.8％),oxacillin(85.4％),and clindamycin(59.8％).Multidrug-resistant S.epidermidis exhibited high resistance rates to penicillin(94.4％),oxacillin(83.3％),and erythromycin(66.7％).Multidrug-resistant K.pneumoniae and E.coli showed high resistance rates against ceftriaxone(88.2％and 100％,respectively)and cefazolin(82.4％and 100％,respectively).Conclusions MDRO infections in dermatology inpatients primarily affect patients with compromised skin barrier,particularly those with pemphi-gus,bullous pemphigoid,and mycosis fungoides.The predominant Gram-positive MDROs are MRSA and S.epidermidis,while the predominant Gram-negative MDROs are K.pneumoniae and E.coli.The most common sites of MDRO infections are the limbs and trunk.Gram-positive MDROs demonstrate high resistance rates to penicillin,oxacillin,clindamycin,and erythromycin,whereas Gram-negative MDROs show high resistance rates to ceftriaxone,cefazolin,and nitro-furantoin.关键词
皮肤创面/多重耐药菌/菌群分布/耐药分析/护理对策Key words
skin wounds/multidrug-resistant organisms/pathogen distribution/drug re-sistance analysis/nursing strategies
