皮肤性病诊疗学杂志2026，Vol.33Issue(5)：388-396,9.DOI:10.3969/j.issn.1674-8468.2026.05.010
P2X7R和NLRP3炎性小体在炎症性皮肤病发病机制中的研究进展
Research progress on P2X7R and NLRP3 inflammasome in the pathogenesis of inflammato-ry skin diseases
陈华君 1牛璐璐 2蒙永霞 1陈木开1
作者信息
- 1. 中山大学附属第一医院,广东 广州 510080
- 2. 佛山市妇幼保健院,广东 佛山 528000
- 折叠
摘要
Abstract
The P2X7 receptor(P2X7R)and the NLRP3 inflammasome constitute a key signa-ling pathway in the regulation of inflammatory responses and play a critical role in various inflam-matory skin diseases.Upon activation by extracellular ATP,P2X7R mediates the activation of NL-RP3 inflammasome through transmembrane ion signaling,thereby driving downstream inflammatory responses.This pathway exhibits heterogeneous regulatory patterns across different diseases,inclu-ding the formation of an ATP-IL-23 positive feedback loop in psoriasis,a LL37-centered interac-tive network in rosacea,as well as positive feedback amplification involving IL-17/IL-1β in hidra-denitis suppurativa and TNF-α in Behçet's disease.This review systematically summarizes the mechanistic roles and targeted therapeutic strategies of P2X7R and NLRP3 in inflammatory skin disorders,aiming to provide a theoretical basis and translational perspective for further mechanistic research and therapeutic development.关键词
炎症性皮肤病/P2X7受体/NLRP3炎性小体Key words
inflammatory skin diseases/P2X7 receptor/NLRP3 inflammasome引用本文复制引用
陈华君,牛璐璐,蒙永霞,陈木开..P2X7R和NLRP3炎性小体在炎症性皮肤病发病机制中的研究进展[J].皮肤性病诊疗学杂志,2026,33(5):388-396,9.
