南京医科大学学报（自然科学版）2026，Vol.46Issue(6)：809-819,11.DOI:10.7655/NYDXBNSN250962
肝窦内皮细胞:慢性肝病进展的"帮凶"?
Liver sinusoidal endothelial cells:"accomplice"in chronic liver disease progression?
摘要
Abstract
Liver sinusoidal endothelial cells(LSEC)are liver-specific endothelial cells.Under physiological conditions,LSECs exhibit open fenestrae,facilitating the efficient bidirectional exchange of small molecules between hepatocytes and blood.They are crucial for maintaining hepatic filtration and metabolic homeostasis,suppressing the activation of hepatic stellate cells(HSC),and modulating hepatic immune responses and tolerance,thereby forming the principal barrier of the liver microcirculation.During liver injury,however,LSECs undergo phenotypic changes—including capillarization,cellular senescence,and endothelial-to-mesenchymal transition.These changes result in increased intrahepatic vascular resistance,impaired transvascular exchange,and enhanced secretion of pro-angiogenic and pro-inflammatory factors.In the absence of timely intervention,this pathological cascade can exacerbate liver damage.Therefore,therapeutic targeting of LSEC dysfunction has emerged as a novel strategy for chronic liver disease.This article systematically elaborates on the dynamic changes and specific mechanistic roles of LSECs in both physiological homeostasis and chronic liver disease,summarizes current therapeutic strategies aimed at LSECs,and also discusses existing research limitations and suggests future directions.关键词
肝窦内皮细胞/慢性肝病/肝星状细胞Key words
liver sinusoidal endothelial cell/chronic liver disease/hepatic stellate cell分类
医药卫生引用本文复制引用
韩汶书,申敏,钱莉..肝窦内皮细胞:慢性肝病进展的"帮凶"?[J].南京医科大学学报（自然科学版）,2026,46(6):809-819,11.基金项目
国家自然科学基金(82400712) （82400712）
江苏省基础研究计划自然科学基金青年基金(BK20230588) （BK20230588）
江苏省高等学校基础科学(自然科学)研究面上项目(23KJB310031) （自然科学）
扬州市自然科学基金(YZ2023165) （YZ2023165）
