内科理论与实践2026，Vol.21Issue(2)：119-123,5.DOI:10.16138/j.1673-6087.2026.02.03
多组学技术在代谢相关脂肪性肝病临床异质性研究中的应用
Multi-omics technologies in the study of clinical heterogeneity of metabolic associated fatty liver disease
摘要
Abstract
Metabolic associated fatty liver disease(MAFLD)is the most prevalent chronic liver disease worldwide and has become an important public health issue.MAFLD not only impairs liver function but is also closely associated with an increased risk of multi-system diseases,including cardiovascular disease,chronic kidney disease,and type 2 diabetes mellitus.However,current treatment for MAFLD still faces challenges such as a lack of effective drugs and significant limitations in drug efficacy.The core challenge lies in the high degree of clinical heterogeneity among MAFLD patients.This article systematically reviews the breakthrough research findings achieved by multi-omics technologies(including genome-wide association analysis,transcriptome sequencing,proteomics,and metabolomics)in deciphering the heterogeneity of MAFLD,and summarizes the MAFLD subtypes and their molecular mechanisms defined based on the above multi-omics characteristics,thereby providing a critical scientific basis for precision risk stratification and the development of personalized therapeutic targets for MAFLD patients.关键词
代谢相关脂肪性肝病/临床异质性/多组学/蛋白质组学/亚型Key words
metabolic associated fatty liver disease/clinical heterogeneity/multi-omics/proteomics/subtype分类
医药卫生引用本文复制引用
丁晶晶,柴进..多组学技术在代谢相关脂肪性肝病临床异质性研究中的应用[J].内科理论与实践,2026,21(2):119-123,5.基金项目
国家科技重大专项(新突发与重大传染病防控)(2025ZD101906400) （新突发与重大传染病防控）
国家自然科学基金杰出青年科学基金项目(82325008) （82325008）
国家自然科学基金青年科学基金项目(82500717) （82500717）
