日用化学品科学2026，Vol.49Issue(6)：20-26,44,8.DOI:10.3969/j.issn.1006-7264.2026.06.004
一种保湿舒缓修护功效组合物及其应用研究
A moisturizing,soothing,and repairing functional composition and its application
蔡敏珊 1彭文 1彭国成 1黄敏 1罗绍强 1许余江胜1
作者信息
- 1. 海龟爸爸羲和实验室,广东 广州 510700
- 折叠
摘要
Abstract
A functional composition with moisturizing,soothing,and repairing properties,based on glucosyl-glycerol and a Lactobacillus/algae extract fermentation product,was developed and incorporated into a stable emulsion system.Its efficacy was systematically evaluated using multidimensional models,including in vitro moisturizing assays,anti-inflammatory assays in HaCaT cells,hyaluronidase inhibition,the hen's egg chorioallantoic membrane(HET-CAM)test,HaCaT cell scratch assay,and human efficacy studies.The results demonstrated that the combination of glucosyl-glycerol and the Lactobacillus/algae extract fermentation product exhibited superior anti-erythema effects compared with either component alone in a histamine-induced skin erythema model.The emulsion containing this composition showed significantly higher skin hydration than the control group at 2 and 6 h(p<0.01),along with significantly reduced trans-epidermal water loss(TEWL)(p<0.01),indicating rapid hydration and sustained moisture retention.The formulation significantly inhibited IL-6 expression(p<0.05)and exhibited a hyaluronidase inhibition rate of 61.15%±5.02%,suggesting effective suppression of inflammatory cascades and hyaluronic acid degradation.The HET-CAM assay confirmed that the formulation was mild and non-irritating.In the HaCaT cell scratch assay,the relative cell migration rate in the emulsion group reached 157.13%compared with the control group(p<0.01),indicating enhanced wound-healing capacity.In a 14-day human study,stratum corneum hydration increased by 19.95%,hemoglobin content decreased by 19.01%,and TEWL decreased by 16.80%.Overall,the emulsion containing this functional composition demonstrated excellent moisturizing,soothing,and repairing properties,and effectively strengthened the skin barrier.关键词
甘油葡糖苷/乳酸杆菌/藻提取物发酵产物/舒缓修护/功效评价/皮肤屏障Key words
glucosyl-glycerol/Lactobacillus/algae extract fermentation product/soothing and repair/efficacy evaluation/skin barrier分类
化学化工引用本文复制引用
蔡敏珊,彭文,彭国成,黄敏,罗绍强,许余江胜..一种保湿舒缓修护功效组合物及其应用研究[J].日用化学品科学,2026,49(6):20-26,44,8.
