山东医药2026，Vol.66Issue(5)：38-43,6.DOI:10.3969/j.issn.1002-266X.2026.05.008
不同脂耐量非肥胖男性高脂餐后血清皮质醇水平变化及其影响因素分析
Postprandial changes in serum cortisol levels after a high-fat meal and their influencing factors in non-obese men with different degrees of fat tolerance
摘要
Abstract
Objective To investigate postprandial changes in serum cortisol levels after a high-fat meal in non-obese men with different degrees of fat tolerance and to analyze the associated factors.Methods A total of 90 male par-ticipants underwent an oral fat tolerance test(OFTT).Based on fasting triglyceride(TG)levels and TG levels at OFTT 4 h,participants were classified into three groups(n=30 each):normal fat tolerance(NFT),impaired fat tolerance(IFT),and hypertriglyceridemia(HTG).All participants received a high-fat meal(1,500 kcal,with 60%of total ener-gy derived from fat).Blood samples were collected at OFTT 0,2,4,and 6 h,and serum cortisol,free fatty acids(FFA),TG,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),fasting blood glucose,and fasting insulin(FINS)were measured.Multivariate linear regression analysis was performed to identify factors associated with cortisol levels.Results Within-group comparisons showed that cortisol and FFA levels decreased initially and then increased after the high-fat meal in all three groups.Cortisol levels reached their nadir at OFTT 4 h(all P<0.05),whereas FFA levels reached their lowest point at OFTT 2 h(all P<0.05).TG levels peaked at OFTT 4 h in all groups(all P<0.05).Between-group comparisons showed that,at baseline,waist circumfer-ence,TG,TC,LDL-C,FFA,and cortisol levels were significantly higher in the HTG group than in the NFT and IFT groups(all P<0.05).At all postprandial time points,significant differences were observed in FFA and TG levels among the three groups(all P<0.05).At OFTT 4 h,cortisol levels were significantly higher in the HTG group than in the NFT and IFT groups(all P<0.05).At OFTT 6 h,cortisol levels were significantly higher in the IFT and HTG groups than in the NFT group(all P<0.05).Multivariate linear regression analysis showed that,after adjustment for confounding fac-tors,preprandial FFA and TG levels were independent risk factors for cortisol levels(all P<0.05),whereas the FFA lev-el at OFTT 6 h was an independent risk factor for serum cortisol levels(P<0.05).Conclusion Serum cortisol levels were higher in non-obese men with more severe impairment of fat tolerance.Fasting FFA and TG levels,as well as serum FFA levels at 6 h postprandially,were independent risk factors for serum cortisol levels.关键词
脂耐量/皮质醇/游离脂肪酸/高脂餐/口服脂肪耐量试验/男性Key words
fat tolerance/cortisol/free fatty acids/high-fat meal/oral fat tolerance test/male分类
医药卫生引用本文复制引用
刘丹丹,任路平,刘晶,田培培,侯艺林,卢亚敏,唐雅乐,宋光耀..不同脂耐量非肥胖男性高脂餐后血清皮质醇水平变化及其影响因素分析[J].山东医药,2026,66(5):38-43,6.基金项目
国家自然科学基金项目(82170878). （82170878）
