陕西中医2026，Vol.47Issue(6)：741-747,7.DOI:10.3969/j.issn.1000-7369.2026.06.004
双酚A对雄性大鼠生殖损伤及海龙黄精散的干预作用
Interventional effects of Hailong Huangjing powder on Bisphenol A-induced reproductive injury in male rats
摘要
Abstract
Objective:To investigate the preventive effects of Hailong Huangjing powder on reproductive dam-age induced by bisphenol A(BPA)in male rats.Methods:SD male rats were used to establish a BPA-induced infertil-ity model.Different doses of Hailong Huangjing powder were administered for preventive and therapeutic interven-tions.Sperm quality,testicular histomorphology,oxidative stress levels,and cell apoptosis were evaluated in each group.Results:BPA exposure significantly reduced sperm progressive motility,total motility,and the percentage of normal sperm(P＜0.05),and caused marked testicular structural damage characterized by vacuolization,cell shed-ding,and decreased Sertoli cell numbers.BPA also reduced the activities of GSH-Px and CAT while increasing MDA levels(P＜0.05),accompanied by a notable increase in cell apoptosis(P＜0.05).Both preventive and therapeutic ad-ministration of Hailong Huangjing powder markedly improved BPA-induced reproductive injury,with the medium-and high-dose groups showing better efficacy.Conclusion:Hailong Huangjing powder effectively prevents and allevi-ates BPA-induced reproductive damage in male rats,and its mechanism may be related to enhancing antioxidant ca-pacity and regulating apoptosis of Sertoli cells.关键词
海龙黄精散/双酚A/生殖毒性/抗氧化/细胞凋亡/精子质量/Sertoli细胞Key words
Hailong Huangjing powder/Bisphenol A/Reproductive toxicity/Antioxidant/Apoptosis/Sperm quality/Sertoli cells分类
医药卫生引用本文复制引用
于珊珊,叶雯佳,李香斌,黄念文,毕焕洲..双酚A对雄性大鼠生殖损伤及海龙黄精散的干预作用[J].陕西中医,2026,47(6):741-747,7.基金项目
国家自然科学基金资助项目(82274532) （82274532）
广东省深圳市自然科学基金资助项目(JCYJ20250604184319026) （JCYJ20250604184319026）
