陕西中医2026，Vol.47Issue(6)：761-766,6.DOI:10.3969/j.issn.1000-7369.2026.06.007
乳腺癌内分泌治疗中医证候研究
TCM syndrome study in breast cancer patients undergoing endocrine therapy
摘要
Abstract
Objective:To investigate the distribution patterns of traditional Chinese medicine(TCM)syndromes in patients with breast cancer undergoing endocrine therapy using factor analysis and cluster analysis.Methods:A cross-sectional study design was adopted.General data and TCM four-diagnosis information were collected from pa-tients receiving endocrine therapy for breast cancer at the Third Affiliated Hospital of Beijing University of Chinese Medicine,Xiamen Hospital of Traditional Chinese Medicine,and Chongqing Hospital of Traditional Chinese Medicine between January 2025 and December 2025.Data were entered into Excel 2019 for frequency analysis,and factor anal-ysis and cluster analysis were performed using SPSS 27.0 to summarize the TCM syndrome characteristics of the pa-tients.Results:A total of 480 patients with breast cancer on endocrine therapy were enrolled.Fifty-four TCM syn-drome items with a frequency ≥10％were retained.The most common symptoms or signs included restless sleep,insomnia,hot flashes,spontaneous sweating,thirst,wiry pulse,thready pulse,forgetfulness,dark red tongue,and soreness and heaviness pain.Factor analysis extracted 21 common factors,which further revealed 12 disease nature syndrome elements,with Yin deficiency,dampness,and Yang deficiency being the most prevalent;and 9 disease loca-tion syndrome elements,mainly involving the kidney,liver,and spleen.Cluster analysis based on the 21 common fac-tors showed that the common syndrome types included liver-kidney deficiency syndrome(42.08％),spleen deficiency with dampness accumulation syndrome(26.25％),liver depression transforming into fire syndrome(16.04％),and Qi-Yin defi-ciency syndrome(15.63％).Conclusion:The disease location in breast cancer patients undergoing endocrine therapy is mainly in the kidney,liver,and spleen,and the TCM syndrome types are predominantly liver-kidney deficiency syndrome,spleen deficiency with dampness accumulation syndrome,liver depression transforming into fire syndrome,and Qi-Yin deficiency syndrome.关键词
乳腺癌/内分泌治疗/中医证型/证素/因子分析/聚类分析Key words
Breast cancer/Endocrine therapy/TCM syndrome types/Syndrome elements/Factor analysis/Cluster analysis分类
医药卫生引用本文复制引用
王璐瑶,张琼,陈宁净,熊志峰,樊英怡,裴晓华..乳腺癌内分泌治疗中医证候研究[J].陕西中医,2026,47(6):761-766,6.基金项目
国家自然科学基金资助项目(82374463) （82374463）
中西医协同慢病管理研究项目(CXZH2024156) （CXZH2024156）
