陕西中医2026，Vol.47Issue(6)：777-781,5.DOI:10.3969/j.issn.1000-7369.2026.06.010
健脾补肾方联合吉西他滨+顺铂化疗方案治疗三阴性乳腺癌临床研究
Clinical study of Jianpi Bushen decoction combined with gemcitabine plus cisplatin chemotherapy regimen in the treatment of triple negative breast cancer
摘要
Abstract
Objective:To explore the clinical efficacy of Jianpi Bushen decoction combined with gemcitabine plus cisplatin(GP)chemotherapy regimen in the treatment of triple negative breast cancer(TNBC).Methods:94 patients with TNBC with spleen-kidney deficiency syndrome were selected for study,and were divided into control group and observation group by simple randomization(random number table method),with 47 cases in each group.GP chemo-therapy regimen and Jianpi Bushen decoction combined with GP chemotherapy regimen were given respectively.The changes of TCM efficacy,short-term solid tumor efficacy,TCM symptoms scores,serological indexes[thymidine ki-nase 1(TK1),platelet to lymphocyte ratio(PLR)and neutrophil to lymphocyte ratio(NLR)]before and after treat-ment were compared between the two groups,and adverse reactions during treatment were recorded.Results:The clinical effective rate and clinical remission rate with 93.62％and 70.21％in observation group were higher than 78.72％and 46.81％in control group(P＜0.05).After the end of treatment,the scores of primary symptoms(ano-rexia and vomiting,chest fullness and stuffiness,cold limbs,alopecia)and secondary symptoms(pale complexion,lassitude,abdominal pain,abdominal distension and abdominal stridor)in the two groups were significantly decreased(P＜0.05),and the scores in observation group were lower(P＜0.05).The expression levels of TK1,PLR and NLR in the two groups were significantly decreased after the end of treatment(P＜0.05),and the levels were lower in ob-servation group(P＜0.05).During treatment,the incidence rates of nausea and vomiting,alopecia,anemia,urinary system abnormalities and liver dysfunction in observation group were lower than those in control group(P＜0.05).Conclusion:Jianpi Bushen decoction combined with GP chemotherapy regimen can significantly enhance the clinical efficacy of TNBC,improve the clinical symptoms,regulate the levels of serum tumor factors and inflammatory fac-tors,and relieve the toxic and side effects of chemotherapy drugs.关键词
三阴性乳腺癌/健脾补肾方/化疗/吉西他滨/顺铂/临床疗效/不良反应Key words
Triple negative breast cancer/Jianpi Bushen decoction/Chemotherapy/Gemcitabine/Cisplatin/Clinical efficacy/Adverse reactions分类
医药卫生引用本文复制引用
李丹,刘芳,曾杏,蒋玓池,蔡娟..健脾补肾方联合吉西他滨+顺铂化疗方案治疗三阴性乳腺癌临床研究[J].陕西中医,2026,47(6):777-781,5.基金项目
湖南省自然科学基金资助项目(2020JJ8066) （2020JJ8066）
