生物骨科材料与临床研究2026，Vol.23Issue(3)：10-15,6.DOI:10.3969/j.issn.1672-5972.2026.03.002
Box-Behnken响应面法优化伤筋止痛液体绷带
Optimization of liquid bandage matrix formulation by Box-Behnken response surface methodology
王学鹏 1龙泽纯 2熊承杰 3胡华 4徐峰3
作者信息
- 1. 武汉科技大学,湖北 武汉,430065
- 2. 湖北医药学院药学院,湖北 十堰,442000
- 3. 中部战区总医院骨科,湖北 武汉,430060
- 4. 中部战区总医院医疗保障中心,湖北 武汉,430060
- 折叠
摘要
Abstract
Objective To optimize the formulation of a liquid bandage for muscular fasciitis relief using the Box-Behnken response surface methodology.Methods Key factors including the pH of the boric acid-sodium hydroxide buffer solution,the amount of propylene glycol,the concentration of polyvinyl alcohol(PVA),and the concentration of water-soluble starch were investigated.A comprehensive evaluation system was constructed based on three indicators:adhesion performance,moisturizing properties,and crosslinking rate.Among them,adhesion was worth 40 points,moisturizing properties and crosslinking rate each 30 points,and the total score of comprehensive evaluation was 100 points.The Box-Behnken response surface methodology was used for experimental design,and multivariate regression analysis was conducted to optimize formulation parameters.Results The optimal formulation was determined as a buffer solution with pH 8.9,0.5 mL of propylene glycol,20%(w/v)PVA concentration,and 15%(w/v)water-soluble starch concentration.Under these conditions,the comprehensive score was 89.74 points.Conclusion The prepared liquid bandage exhibited moderate adhesion,good moisturizing properties,and rapid crosslinking.关键词
液体绷带/处方优化/Box-Behnken响应面法Key words
Liquid bandage/Formulation optimization/Box-Behnken response surface methodology分类
医药卫生引用本文复制引用
王学鹏,龙泽纯,熊承杰,胡华,徐峰..Box-Behnken响应面法优化伤筋止痛液体绷带[J].生物骨科材料与临床研究,2026,23(3):10-15,6.
