生物技术通报2026，Vol.42Issue(5)：27-36,10.DOI:10.13560/j.cnki.biotech.bull.1985.2026-0385
共生功能体及其在农业、环境及健康领域的应用
Holobiont and Its Applications in Agriculture,Environment and Health
摘要
Abstract
In nature,plant and animal hosts are never isolated individuals.Instead,they are tightly integrated with their resident microbiomes into highly complex living systems.In recent years,the holobiont and hologenome theories have challenged the traditional binary symbiotic model,emphasizing that the host and its associated microbiome constitute an indivisible ecological and co-evolutionary unit.This review systematically examines the mechanisms of holobiont assembly and homeostasis maintenance.First,we elucidate the decisive roles of host genetic background,immune regulation,and environmental factors in microbial community assembly.Second,we explore the balance between stability and plasticity of vertical,horizontal,and mixed transmission strategies in maintaining the intergenerational homeostasis of holobionts,and reveal the co-evolutionary mechanisms of host-microbiome interactions in metabolic complementation and immune interplay.On this basis,the review discusses the translational application potential and current challenges of holobiont-targeted strategies in the early warning of agricultural diseases,crop trait improvement,complex disease interventions,and degraded ecosystem restoration.Future research urgently needs to shift from correlational descriptions to mechanistic elucidation,focusing on the identification and validation of core functional components.Constructing highly sensitive microbiome-based monitoring-intervention systems,and integrating technologies such as synthetic microbial communities,will provide solid theoretical guidance and a technical framework for sustainable agricultural development,human health management,and global ecological governance.关键词
共生功能体/全基因组/微生物组组装/协同进化Key words
holobiont/hologenome/microbiome assembly/co-evolution引用本文复制引用
潘潜倩,王蒙岑..共生功能体及其在农业、环境及健康领域的应用[J].生物技术通报,2026,42(5):27-36,10.基金项目
国家自然科学基金项目(32525051),浙江省自然科学基金项目(LD25C140002),杭州市自然科学基金项目(2024SZRZDC130001) （32525051）
