实用医学杂志2026，Vol.42Issue(11)：1949-1958,10.DOI:10.3969/j.issn.1006-5725.2026.11.008
功能化外泌体在骨科疾病治疗中的研究进展
Research advances in functionalized exosomes for orthopedic disease treatment
摘要
Abstract
With the continuous development of society and the progress of medical science,the treatments for orthopedic diseases are gradually evolving towards precision medicine.As natural nanovesicles,exosomes pos-sess outstanding biocompatibility and targeting abilities.Through functional modifications including genetic engi-neering,drug loading,and surface modification,exosomes can precisely facilitate bone regeneration,regulate bone metabolism,and reshape the immune micro-environment.They show remarkable potential in the treatment of orthopedic disorders such as fractures,osteoarthritis,and osteoporosis.Nevertheless,there are still challenges in standardized preparation,efficacy evaluation,safety assessment,and clinical translation.This article systemati-cally reviews the most recent advances in functionalized exosomes for the treatment of orthopedic diseases,encom-passing their sources,preparation methods,functionalization strategies,and mechanisms of action.It summarizes the application progress of functionalized exosomes in orthopedic therapy,discusses the current technical chal-lenges and future development directions,and is of great significance for the translation of functionalized exosomes from laboratory research to clinical application in orthopedics.关键词
骨折/骨关节炎/骨质疏松/外泌体/miRNAKey words
fracture/osteoarthritis/osteoporosis/exosomes/miRNA分类
医药卫生引用本文复制引用
马乐乐,王岩,崔洪伟,张慧,陈毓婧,董本超,杨培川,马剑雄..功能化外泌体在骨科疾病治疗中的研究进展[J].实用医学杂志,2026,42(11):1949-1958,10.基金项目
国家自然科学基金青年项目(编号:82405109) （编号:82405109）
天津市教委科研计划项目(编号:2024ZXZD001) （编号:2024ZXZD001）
天津市科技计划项目(编号:25JCZDJC01350) （编号:25JCZDJC01350）
天津市科技重大专项与工程公共卫生项目重点项目(编号:25ZXWZSY00010) （编号:25ZXWZSY00010）
