医学新知2026，Vol.36Issue(5)：495-502,8.DOI:10.12173/j.issn.1004-5511.202603034
巢式病例对照研究的方法学进展及其在临床研究中的应用
Methodological advances and application in clinical research of nested case-control studies
摘要
Abstract
Nested case-control study(NCCS)is a derived type of traditional case-control study.As an observational research method,it has many advantages and provides an efficient,economic and reliable method for clinical research.This article elaborates on the progress of NCCS and their applications in clinical research from the perspective of clinical epidemiological methodology.The principles,classifications,application conditions,research design,implementation points,as well as advantages and disadvantages of NCCS are comprehensively introduced.Especially regarding the key issues in selecting research types and control groups for current design and implementation,this article has put forward rational suggestions.This article aims to deepen clinical doctors'correct understanding and standardized application in clinical research of NCCS,and provide methodological reference for improving the scientific and reliable evidence of NCCS.关键词
巢式病例对照研究/分类标准/发病密度/匹配/研究设计Key words
Nested case-control study/Classification standard/Incidence density/Matching/Research design分类
医药卫生引用本文复制引用
陆春利,夏婷婷,邬娜,向颖,李亚斐..巢式病例对照研究的方法学进展及其在临床研究中的应用[J].医学新知,2026,36(5):495-502,8.基金项目
"癌症、心脑血管、呼吸和代谢性疾病防治研究"国家科技重大专项(2025ZD0551600) （2025ZD0551600）
