医学新知2026，Vol.36Issue(5)：534-540,7.DOI:10.12173/j.issn.1004-5511.202507037
血清AACT在前列腺癌早期诊断中的作用研究
Exploration of serum AACT protein as a biomarker for early diagnosis of prostate cancer
摘要
Abstract
Objective To investigate the expression,diagnostic efficacy,and clinical significance of α1-antichymotrypsin(AACT)encoded by SERPINA3 in prostate cancer(PCa).Methods Publicly-available database analysis evaluated SERPINA3 expression and its correlation with clinical features.Serum samples from treatment-naïve PCa patients,benign prostatic hyperplasia(BPH)patients and healthy controls collected at Zhongnan Hospital of Wuhan University were analyzed via ELISA for AACT expression levels.The receiver operating characteristic curve and its area under the curve(AUC)were assessed for diagnostic performance.ssGSEA analyzed associations between SERPINA3 expression and pro-oncogenic pathways using TCGA data.Results SERPINA3 expression was significantly elevated in PCa patients versus controls(P<0.05).ELISA revealed higher serum AACT levels in PCa compared to BPH patients(P<0.001).The AUC value of distinguishing PCa from BPH and healthy control was 0.968[95％CI(0.930,0.998)]and 0.958[95％CI(0.910,0.994)],respectively.ssGSEA demonstrated strong correlations between SERPINA3 and pro-tumor pathways(apoptosis,DNA repair,metabolism)(P<0.001).Conclusion Serum AACT exhibits high clinical potential for early PC diagnosis.关键词
SERPINA3基因/α1-抗胰凝乳蛋白酶/前列腺癌/早期诊断Key words
SERPINA3 gene/α1-antichymotrypsin/Prostate cancer/Early diagnosis分类
医药卫生引用本文复制引用
周健勇,谢欢,范俊丽,李一荣,李欣然..血清AACT在前列腺癌早期诊断中的作用研究[J].医学新知,2026,36(5):534-540,7.基金项目
国家自然科学基金青年科学基金项目(82102793) （82102793）
国家重点研发计划"主动健康和老龄化科技应对"重点专项(2021YFC2009302) （2021YFC2009302）
