现代畜牧科技Issue(6)：12-16,5.DOI:10.19369/j.cnki.2095-9737.2026.06.004
绵羊BMP15基因FecXGr突变及其生物信息学分析
FecXGr Mutation in the BMP15 Gene of Sheep and Its Bioinformatic Analysis
摘要
Abstract
To investigate the potential impact of the FecXGr mutation in the sheep bone morphogenetic protein 15(BMP15)gene on the function of its encoded protein,this study employed bioinformatics methods to compare the physicochemical properties,secondary/tertiary structures,post-translational modification sites,and cross-species conservation of the protein before and after the mutation.Results indicate that the FecXGr mutation did not alter the BMP15 protein's basicity,hydrophilicity,secretory properties,or three conserved glycosylation sites.It only slightly increased the protein molecular weight to 44.91 kDa and total atom count to 6 347;reduced phosphorylation sites by one;The proportion of α-helices and extended chains in the secondary structure decreased,while the proportion of disordered regions increased.β-folds and the tertiary structure remained stable.Cross-species conservation analysis indicated that sheep BMP15 nucleotide sequences and their encoded protein sequences showed the highest consistency with ruminants(goats,cattle)and the lowest with humans,demonstrating high conservation of this gene in ruminants.This study provides theoretical insights for elucidating the mechanism by which the FecXGr mutation regulates sheep reproductive performance and for molecular breeding.关键词
BMP15/FecXGr突变/生物信息学Key words
BMP15/FecXGr mutation/bioinformatics分类
农业科技引用本文复制引用
曹贵玲,刘晴,侯森轩,储明星..绵羊BMP15基因FecXGr突变及其生物信息学分析[J].现代畜牧科技,2026,(6):12-16,5.基金项目
中央级公益性科研院所基本科研业务费专项(Y2024YJ08) （Y2024YJ08）
财政部和农业农村部国家现代农业产业技术体系(CARS-38-02) （CARS-38-02）
中国农业科学院科技创新工程(ASTIP-IAS13) （ASTIP-IAS13）
