现代畜牧科技Issue(6)：21-24,4.DOI:10.19369/j.cnki.2095-9737.2026.06.006
桑黄硒多糖对甲基硫氧嘧啶诱导小鼠肝损伤的保护作用
Protective Effect of Sanghuang Selenium Polysaccharide on Liver Injury Induced by Methylthiouracil in Mice
摘要
Abstract
The aim of this experiment is to investigate the protective effect and potential mechanism of Sanghuang selenium polysaccharide(SHXDT)on a mouse liver injury model induced by methylthiouracil(MTU).The experiment randomly divided the mice into 5 groups,namely the normal control group(NC),the model group,and the low,medium,and high dose groups(SHXDT).The model group and each treatment group of mice were intraperitoneally injected with MTU to create a liver injury model,while the normal control group was injected with an equal amount of physiological saline.After 3 weeks of continuous treatment,the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total bilirubin(TBIL)in the serum of mice were measured to evaluate the degree of liver damage;Measure the content of malondialdehyde(MDA),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activity in liver tissue to assess oxidative stress levels;Observe the pathological changes of liver tissue through hematoxylin eosin(HE)staining.The results showed that compared with the model group,the serum ALT,AST,and TBIL levels of mice in each dose group of SHXDT were significantly reduced;The activities of SOD and GSH-Px also significantly decreased;The pathological damage to the liver has been improved.Conclusion:SHXDT has a significant protective effect on MTU induced liver injury in mice.关键词
桑黄硒多糖/MTU/血液生化指标/肝损伤Key words
Sanghuang selenium polysaccharide/MTU/blood biochemical indicators/liver injury分类
医药卫生引用本文复制引用
宋轩蕊,王皓涵,符清玲,薛菲,曾好,王锋,宫汝淳,李小丽..桑黄硒多糖对甲基硫氧嘧啶诱导小鼠肝损伤的保护作用[J].现代畜牧科技,2026,(6):21-24,4.基金项目
海南科技职业大学科学研究项目(HKKY2024-80) （HKKY2024-80）
