养殖与饲料2026，Vol.25Issue(6)：41-45,5.DOI:10.13300/j.cnki.cn42-1648/s.2026.06.009
挪威红牛×荷斯坦奶牛杂交代与荷斯坦奶牛的抗病力差异分析
Differences in the disease resistance between crossbred generation of Norwegian Red×Holstein cattle and Holstein cattle
摘要
Abstract
[Objectives]The differences in the disease resistance and recovery time between Norwegian Red×Holstein crossbred dairy-beef cattle(hereinafter referred to as Nor-Hol cattle)and Holstein dairy cattle(hereinafter referred to as Holstein cattle)during the occurrence of diseases in digestive tract were studied to provide a basis for healthy dairy farming and crossbreeding at the context of"dual-purpose dairy-beef produc-tion."[Methods]8 calves aged 1-3 months and weighted 72-81 kg,9 heifers aged 16 months and weighted 320-343 kg,9 adult cows aged 1.7-6 years and weighted 410-692 kg,and 9 dry cows aged 4-6 years and weighted 556-692 kg,totaling 70 animals,were randomly selected from each of the two cattle strains under the same con-ditions of environment,feeding,and management.A double-antibody sandwich enzyme-linked immunosorbent assay(ELISA)was used to measure the content of interleukins,complement components,interferons,immuno-globulins,and major histocompatibility complex(MHC)in the serum from two strains at different stages of growth.The clinical outcomes of the two strains under identical treatment conditions were recorded.[Results]The average increase in the content of IL-2 in the serum from calves,heifers,adult cows,and dry cows of Nor-Hol cattle was 41.11%,45.49%,47.23%,and 39.91%compared with that from Holstein cattle.The average in-crease in the content of IL-6 was 45.15%,42.56%,46.98%,and 51.54%,respectively.The average increase in the content of complement C3 was 29.47%,34.16%,23.58%,and 23.59%,respectively.The average increase in the content of C4 was 210.36%,215.84%,204.53%,and 200.23%,respectively.The average increase in the content of total complement CH50 was 65.83%,66.79%,53.64%,and 55.02%,respectively.The average con-tent of IFN-γ and MHC in serum from Nor-Hol cattle at the late stage of infection was 486.22%,501.47%,496.21%,and 490.89%,712.94%,1086.21%,1281.08%,and 1409.75%higher than that from Holstein cattle.The average clinical recovery time for Nor-Hol cattle was 0.19 days,2.21 days,2.98 days,and 2.95 days shorter than that for Holstein cattle.[Conclusions]The content of multiple immune-related cytokines in serum from Nor-Hol cattle under conditions of disease in digestive tract was higher compared with that in Holstein cattle,indicating that its disease resistance is stronger and its recovery is faster.The Nor-Hol cattle can be used as a preferred strain for crossbreeding of regional cattle with dual-purpose of dairy-beef.关键词
挪威红牛/荷斯坦奶牛/细胞因子检测/抗病力/杂交育种/免疫水平Key words
Norwegian Red cattle/Holstein cattle/detection of cytokine/disease resistance/crossbreed-ing/level of immune引用本文复制引用
杨阳,汪波,窦立静,陈强斌..挪威红牛×荷斯坦奶牛杂交代与荷斯坦奶牛的抗病力差异分析[J].养殖与饲料,2026,25(6):41-45,5.基金项目
新疆生产建设兵团重点领域科技攻关项目(2023AB009-02) （2023AB009-02）
