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EBV nuclear antigen 1 hijacks DDX5/BZLF1 axis to facilitate viral lytic replication

Li Yang Jianhong Lu Shuyu Xin Shen Li Pengfei Cao Zeyu Sun Mingjuan Jiang Yujie Xin Xiaoling Su Jing Yang

中国病毒学2026，Vol.41Issue(2)：314-328,15.

中国病毒学2026，Vol.41Issue(2)：314-328,15.DOI:10.1016/j.virs.2026.03.012

EBV nuclear antigen 1 hijacks DDX5/BZLF1 axis to facilitate viral lytic replication

Li Yang ¹Jianhong Lu ²Shuyu Xin ¹Shen Li ¹Pengfei Cao ³Zeyu Sun ⁴Mingjuan Jiang ¹Yujie Xin ¹Xiaoling Su ⁴Jing Yang¹

作者信息

1. Department of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,China
2. Department of Medical Microbiology,Xiangya School of Basic Medical Sciences,Central South University,Changsha 410013,China||Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,China||Department of Microbiology,School of Basic Medical Sciences,Xinjiang Medical University,Urumqi 830017,China
3. Key Laboratory of Cancer Carcinogenesis and Invasion of Chinese Ministry of Education,NHC Key Laboratory of Carcinogenesis,Central South University,Changsha 410078,China
4. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,The First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China
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摘要

关键词

Epstein-Barr virus(EBV)/Epstein-Barr virus nuclear antigen 1(EBNA1)/Dead-box helicase 5(DDX5)/FL118/Lytic replication

Key words

Epstein-Barr virus(EBV)/Epstein-Barr virus nuclear antigen 1(EBNA1)/Dead-box helicase 5(DDX5)/FL118/Lytic replication

引用本文复制引用

Li Yang,Jianhong Lu,Shuyu Xin,Shen Li,Pengfei Cao,Zeyu Sun,Mingjuan Jiang,Yujie Xin,Xiaoling Su,Jing Yang..EBV nuclear antigen 1 hijacks DDX5/BZLF1 axis to facilitate viral lytic replication[J].中国病毒学,2026,41(2):314-328,15.

基金项目

We thank Prof.Sai Wah Tsao(The University of Hong Kong,Hong Kong SAR,China)and Prof.Xin Li(Shenzhen Hospital of Southern Medical University,Shenzhen,China)for providing the HONE1-EBV cell line.We are also grateful to Prof.Ronald N.Harty(University of Pennsylvania,Philadelphia,PA,USA)for providing the pCAGGS vector.Additionally,we acknowledge the Top-Notch Innovation Base of Basic Medicine,Central South University,for instrumental support with the inverted fluorescence microscope.This work was supported by the Na-tional Natural Science Foundation of China(82272981,32470171,82370612),the National Key Research and Development Program(2022YFA1303801),and the Zhejiang Provincial Natural Science Foundation of China(LTGC24C050002). （The University of Hong Kong,Hong Kong SAR,China）

中国病毒学

ISSN：1003-5125

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