首页|期刊导航|中国病毒学|Establishment of severe in vitro and in vivo infection models for coxsackievirus B4 and their application in identifying viral virulence determinants

Establishment of severe in vitro and in vivo infection models for coxsackievirus B4 and their application in identifying viral virulence determinants

Haoyi Liu Rong Zhou Qian Liu Wenkuan Liu Xianglin Xuan Bizhen Tang Huan Wang Li Zhang Shuyan Qiu Chuncong Mo Xiao Li Xingui Tian

中国病毒学2026，Vol.41Issue(2)：343-354,12.

中国病毒学2026，Vol.41Issue(2)：343-354,12.DOI:10.1016/j.virs.2026.04.003

Establishment of severe in vitro and in vivo infection models for coxsackievirus B4 and their application in identifying viral virulence determinants

Haoyi Liu ¹Rong Zhou ¹Qian Liu ²Wenkuan Liu ¹Xianglin Xuan ²Bizhen Tang ²Huan Wang ³Li Zhang ⁴Shuyan Qiu ⁴Chuncong Mo ¹Xiao Li ¹Xingui Tian¹

作者信息

1. State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,China||China-Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory,Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases,Guangdong Provincial Key Laboratory of Respiratory Disease Research,Guangzhou Medical University,Guangzhou 511436,China
2. Scientific Research Center,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangdong Pharmaceutical University,Guangzhou 510062,China
3. Scientific Research Center,The First Affiliated Hospital of Guangdong Pharmaceutical University,Guangdong Pharmaceutical University,Guangzhou 510062,China||Kunming Medical University Haiyuan College,Kunming 650106,China
4. State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,Joint International Research Laboratory of Respiratory Health,Guangdong Basic Research Center of Excellence for Respiratory Medicine,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510182,China
折叠

摘要

关键词

Coxsackievirus B4(CVB4)/Severe infection/Infection model/Neurovirulence/Viral virulence determinant

Key words

Coxsackievirus B4(CVB4)/Severe infection/Infection model/Neurovirulence/Viral virulence determinant

引用本文复制引用

Haoyi Liu,Rong Zhou,Qian Liu,Wenkuan Liu,Xianglin Xuan,Bizhen Tang,Huan Wang,Li Zhang,Shuyan Qiu,Chuncong Mo,Xiao Li,Xingui Tian..Establishment of severe in vitro and in vivo infection models for coxsackievirus B4 and their application in identifying viral virulence determinants[J].中国病毒学,2026,41(2):343-354,12.

基金项目

We thank Dr.Zheng Deng(Guangzhou Medical University,China)for helpful discussions and comments during manuscript preparation.We also thank Yinghua Zhou and Jing Ma for technical assistance.This study was supported by the National Science and Technology Major Project of China(2018ZX10102001).The funders had no role in the study design,data collection,data interpretation,or decision to submit the manuscript for publication. （Guangzhou Medical University,China）

中国病毒学

ISSN：1003-5125

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