中国肺癌杂志2026，Vol.29Issue(4)：286-293,8.DOI:10.3779/j.issn.1009-3419.2026.101.08
巨噬细胞胞葬驱动肺癌微环境结构重塑与血管生成的机制及临床干预前景
Mechanisms of Macrophage Efferocytosis-driven Remodeling of Lung Cancer Microenvironment Structure and Angiogenesis and Prospects for Clinical Intervention
秦钰 1岳红梅 2王永清 1朱张璠 1杨帆1
作者信息
- 1. 730000 兰州,兰州大学第一临床医学院
- 2. 730000 兰州,兰州大学第一临床医学院||兰州大学第一医院呼吸与危重症医学科
- 折叠
摘要
Abstract
Lung cancer is one of the most prevalent and lethal malignant tumors worldwide.In recent years,im-mune checkpoint inhibitors have significantly improved the survival outcomes of some patients with advanced non-small cell lung cancer;however,primary and acquired resistance remain important barriers limiting their clinical efficacy.Research has revealed that structural remodeling of the tumor microenvironment(TME)is one of the key factors involved in immunother-apy resistance.Efferocytosis is an important process by which tumor-associated macrophages clear apoptotic cells.In the lung cancer TME,the high apoptotic cell burden can lead to persistent activation of efferocytosis.Studies have shown that sustained efferocytosis is not merely a process of cellular debris clearance,but can also induce metabolic reprogramming in macrophages,including dysregulated lipid metabolism and enhanced glycolysis,and promote the secretion of immunosuppressive and tissue-repair-related factors.These changes further promote pathological angiogenesis,activation of cancer-associated fibroblasts,and excessive extracellular matrix deposition,thereby driving structural remodeling of the TME and forming an immune-excluded microenvironment characterized by vascular abnormalities and stromal fibrosis.This process restricts effector T-cell infiltration and impairs the efficacy of immune checkpoint inhibitors.This review describes the molecular mechanisms of macrophage ef-ferocytosis in the lung cancer TME,focusing on its regulatory roles in metabolic reprogramming,pathological angiogenesis,and stromal fibrosis,and discusses potential therapeutic strategies targeting efferocytosis-related signaling pathways and TME structural remodeling,aiming to provide new insights into overcoming immunotherapy resistance in lung cancer.关键词
肺肿瘤/巨噬细胞/胞葬/肿瘤微环境/代谢重编程/血管生成Key words
Lung neoplasms/Macrophages/Efferocytosis/Tumor microenvironment/Metabolic reprogramming/Angiogenesis引用本文复制引用
秦钰,岳红梅,王永清,朱张璠,杨帆..巨噬细胞胞葬驱动肺癌微环境结构重塑与血管生成的机制及临床干预前景[J].中国肺癌杂志,2026,29(4):286-293,8.
