中国肺癌杂志2026，Vol.29Issue(4)：294-301,8.DOI:10.3779/j.issn.1009-3419.2026.102.11
非小细胞肺癌局部治疗ctDNA-MRD监测研究进展
Research Advances in ctDNA-MRD Monitoring in Local Treatment for Non-small Cell Lung Cancer
摘要
Abstract
Non-small cell lung cancer(NSCLC)remains at risk of recurrence after local treatment,and early iden-tification of molecular residual disease before radiological progression is an important issue in risk stratification.Circulating tumor DNA(ctDNA)-based molecular residual disease(MRD)monitoring provides a promising molecular tool for recurrence risk assessment,response evaluation,and subsequent treatment stratification.However,surgery,thermal ablation,definitive chemoradiotherapy,and stereotactic body radiotherapy differ in tumor burden changes,tissue injury,and DNA release and clearance,leading to uncertainty regarding sampling time points,result interpretation,and clinical utility.This review sum-marizes recent advances in ctDNA-MRD monitoring after local treatment for NSCLC,focusing on ctDNA kinetics,candidate assessment windows,assay platform differences,prognostic value,and translational limitations in perioperative,thermal abla-tion,and radiotherapy settings.Current evidence suggests that perioperative ctDNA-MRD status is associated with pathologi-cal response,recurrence risk,and survival outcomes.In contrast,direct evidence after thermal ablation and stereotactic body radiotherapy remains limited,and proposed sampling time points should be regarded as candidate assessment windows rather than standardized recommendations.Further studies with standardized sampling,assay validation,and prospective interven-tional designs are needed to clarify the clinical value of ctDNA-MRD in adjuvant treatment selection,intensified surveillance,and individualized management.关键词
肺肿瘤/循环肿瘤DNA/分子残留病灶/局部治疗/预后Key words
Lung neoplasms/Circulating tumor DNA/Molecular residual disease/Local treatment/Prognosis引用本文复制引用
李泽宇,王宇飞,吴永坤,郭占林..非小细胞肺癌局部治疗ctDNA-MRD监测研究进展[J].中国肺癌杂志,2026,29(4):294-301,8.基金项目
This paper was supported by the grants from Wu Jieping Medical Foundation(No.320675014320,to Zhanlin GUO)and Natural Science Foundation of Inner Mongolia Autonomous Region(No.2024SHZR0409,to Yufei WANG). 本文受吴阶平医学基金会项目(No.320675014320)和内蒙古自治区自然科学基金项目(No.2024SHZR0409)资助 （No.320675014320,to Zhanlin GUO）
