局解手术学杂志2026，Vol.35Issue(6)：483-486,4.DOI:10.11659/jjssx.09E025009
丙泊酚靶控输注复合艾司氯胺酮在经鼻内窥镜手术中的应用效果
Application effect of propofol target-controlled infusion combined with esketamine in endoscopic nasal surgery
摘要
Abstract
Objective To investigate the influence of propofol target-controlled infusion combined with esketamine on recovery quality and postoperative pain of patients undergoing endoscopic nasal surgery.Methods A total of 102 patients who were scheduled to receive endoscopic nasal surgery were selected and randomly divided into the observation group and the control group,with 51 cases in each group.Patients in the control group were anesthetized with propofol target-controlled infusion,and patients in the observation group were anesthetized with propofol target-controlled infusion combined with esketamine.The fluctuations of heart rate(HR)and mean arterial pressure(MAP)of patients during perioperative period in the two groups were recorded and compared.The visual analogue scale(VAS)was used to assess the pain degree of patients.The Ramsay sedation scores during the anesthesia recovery period and the incidence of agitation during the recovery period in the two groups of patients were compared.The postoperative recovery indicators and the occurrence of adverse reactions of the two groups of patients were statistically analyzed.Results Compared with control group,the HR and MAP of patients in the observation group at each time point during the operation were lower,the VAS scores at 2 hours and 12 hours after the operation were lower,the proportion of patients with high Ramsay sedation score was higher,and the incidence of agitation during the recovery period was lower,the differences were all statistically significant(P<0.05).There were no significant differences in the postoperative recovery indicators or the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion Propofol target-controlled infusion combined with esketamine for endoscopic nasal surgery can significantly relieve the early postoperative pain,and optimize the recovery quality,and it does not significantly increase the risk of occurrence of postoperative adverse reactions,with high clinical safety.关键词
丙泊酚/靶控输注/艾司氯胺酮/经鼻内窥镜手术/苏醒质量Key words
propofol/target-controlled infusion/esketamine/endoscopic nasal surgery/recovery quality分类
医药卫生引用本文复制引用
夏克枢,陈勇,梁孟秋,许明星..丙泊酚靶控输注复合艾司氯胺酮在经鼻内窥镜手术中的应用效果[J].局解手术学杂志,2026,35(6):483-486,4.基金项目
四川省医学会镇痛镇静(宜昌人福)专项科研项目(2024RF02) （宜昌人福）
